Gut Liver.
2015 Jul;9(4):494-501. 10.5009/gnl14010.
Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial
- Affiliations
-
- 1Institute for Digestive Research, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
- 2Division of Gastroenterology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea. kchuh2020@hanmail.net
- 3Division of Gastroenterology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
- 4Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 5Division of Gastroenterology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 6Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 7Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 8Division of Gastroenterology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 9Biostatistical Consulting Unit, Soonchunhynag University College of Medicine, Seoul, Korea.
- 10Division of Gastroenterology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
- 11Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 12Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- KMID: 2160633
- DOI: http://doi.org/10.5009/gnl14010
Abstract
- BACKGROUND/AIMS
We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety.
METHODS
We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups.
RESULTS
A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05).
CONCLUSIONS
The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.
Keyword
MeSH Terms
-
Adult
Aged
Cathartics/*administration & dosage
Citrates/*administration & dosage
Citric Acid/*administration & dosage
Colon/*drug effects/surgery
*Colonoscopy
Drug Combinations
Drug Therapy, Combination/methods
Female
Humans
Intention to Treat Analysis
Laxatives/*administration & dosage
Male
Middle Aged
Organometallic Compounds/*administration & dosage
Patient Compliance
Patient Satisfaction
Picolines/*administration & dosage
Polyethylene Glycols/*administration & dosage
Preoperative Care/methods/psychology
Single-Blind Method
Young Adult
Cathartics
Citrates
Citric Acid
Drug Combinations
Laxatives
Organometallic Compounds
Picolines
Polyethylene Glycols
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