J Korean Med Sci.  2015 Jun;30(6):710-715. 10.3346/jkms.2015.30.6.710.

Stereotactic Body Radiation Therapy for Low- to Intermediate-risk Prostate Adenocarcinoma

Affiliations
  • 1Department of Radiation Oncology, Gyeongsang National University School of Medicine, Jinju, Korea. jsk92@gnu.ac.kr
  • 2Department of Urology, Gyeongsang National University School of Medicine, Jinju, Korea.
  • 3Institute of Health Science, Gyeongsang National University, Jinju, Korea.

Abstract

The aim of the present study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) for low- to intermediate-risk prostate adenocarcinoma. Thirty-nine patients were retrospectively reviewed. The SBRT was delivered using the CyberKnife with the fiducial tracking method combined with In-tempo imaging. The gross target volume, which included the prostate only, was delineated on the fused CT/MRI scans. The prescription dose was delivered every other day as 5 fractions of 7.5 Gy. Venous blood was obtained before and after SBRT to assess the prostate-specific antigen (PSA) level. Toxicity was evaluated using the CTCAE, v4.03. The median follow-up time was 30.0 months. The median initial PSA level was 7.7 ng/mL. PSA levels decreased in all patients treated with SBRT, and after 5 months, the median PSA was less than 2 ng/mL. The rate of overall 3-yr actuarial biochemical failure free survival was 93.9%. Acute side effects were generally comparable with those of previous studies. The PSA change and toxicity after SBRT for low- to intermediate-risk prostate adenocarcinoma indicates favorable biochemical responses and tolerable levels of toxicity. Additionally short course treatment may produce cost benefit and convenience to patients.

Keyword

Prostate Neoplasms; Stereotactic Body Radiation Therapy; Cyberknife Radiosurgery; Prostate-Specific Antigen

MeSH Terms

Adenocarcinoma/*diagnosis/*surgery
Aged
Aged, 80 and over
Humans
Male
Middle Aged
Prostatic Neoplasms/*diagnosis/*surgery
Radiosurgery/*methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Image-Guided/*methods
Risk Assessment
Treatment Outcome

Figure

  • Fig. 1 Example of CyberKnife SBRT treatment plan showing an axial view in a 70-yr old man who was diagnosed with adenocarcinoma of the prostate (cT1c; initial PSA: 3.01; GS: 7).

  • Fig. 2 Change of median PSA value with IQR after SBRT (25%-75%).

  • Fig. 3 BFFS for the low- to intermediate-risk group patients with prostate adenocarcinoma.


Cited by  1 articles

Analysis of Motion-dependent Clinical Outcome of Tumor Tracking Stereotactic Body Radiotherapy for Prostate Cancer
Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Jin Ho Song, Yun Hee Lee, In Bong Ha, Sung Chul Kam, Jeong Seok Hwa, Jae Seog Hyun, Jungmo Do, Dong Hyeok Jeong, Hojin Jeong
J Korean Med Sci. 2018;33(14):.    doi: 10.3346/jkms.2018.33.e107.


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