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The clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort

Suh J, Yuk HD, Kang M, Tae BS, Ku JH, Kim HH, Kwak C, Jeong CW

Purpose: To evaluate the clinical impact of strict selection criteria for active surveillance (AS) of prostate cancer in a Korean population. Materials and Methods: A single-center, prospectively collected AS cohort from...
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Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer

Byun YJ, Piao XM, Jeong P, Kang HW, Seo SP, Moon SK, Lee JY, Choi YH, Lee HY, Kim WT, Lee SC, Cha EJ, Yun SJ, Kim WJ

Purpose: MicroRNAs (miRNAs) are small non-coding RNAs and are involved in the development, proliferation, and pathogenesis of prostate cancer (PCa). Urinary miRNAs are promising non-invasive biomarkers for PCa diagnosis because...
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2020 Korean guidelines for the management of metastatic prostate cancer

Kim IH, Shin SJ, Kang BW, Kang J, Kim D, Kim M, Kim JY, Kim CK, Kim HJ, Maeng CH, Park K, Park I, Bae WK, Sohn BS, Lee MY, Lee JL, Lee J, Lim ST, Lim JH, Chang H, Jung JY, Choi YJ, Kim YS, Cho J, Joung JY, Park SH, Lee HJ

In 2017, Korean Society of Medical Oncology (KSMO) published the Korean management guideline of metastatic prostate cancer. This paper is the 2nd edition of the Korean management guideline of metastatic...
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New Androgen Receptor Axis-Targeted Agents inthe Treatment of Nonmetastatic Castration-ResistantProstate Cancer: From Bench to Clinical Trials

Hong JH

Bone metastasis is a common sign of disease progression in nonmetastatic castration-resistant prostate cancer(nmCRPC). It has been known to be associated with significant morbidity and mortality. Delaying or preventingdevelopment of...
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Prediction of pathologic upgrading in Gleason score 3+4 prostate cancer: Who is a candidate for active surveillance?

Pham DM, Kim JK, Lee S, Hong SK, Byun SS, Lee SE

Purpose: Whether active surveillance (AS) can be safely extended to patients with Gleason score (GS) 3+4 prostate cancer is highly debated. We examined the incidence and predictors of upgrading among...
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Correlation between Gleason score distribution and Prostate Health Index in patients with prostate-specific antigen values of 2.5–10 ng/mL

Choi J, Kang M, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM

Purpose: To determine the clinical significance and correlation between the Prostate Health Index (PHI) and Gleason score in patients with a prostate-specific antigen (PSA) value of 2.5–10 ng/mL. Materials and Methods:...
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Subclassification of pathologically organ-confined (pT2) prostate cancer does not significantly predict postoperative outcomes in Korean males

Lee MH, Lee S, Hong SK, Byun SS, Lee SE

PURPOSE: We evaluated the prognostic association of pT2 subclassification with the oncological outcomes in patients with prostate cancer (PCa) who underwent radical prostatectomy (RP) in South Korea. MATERIALS AND METHODS: We...
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Enzalutamide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: A retrospective Korean multicenter study in a real-world setting

Jung SI, Kim MS, Jeong CW, Kwak C, Hong SK, Kang SH, Joung JY, Lee SH, Yun SJ, Kim TH, Park SW, Jeon SS, Kang M, Lee JY, Chung BH, Hong JH, Ahn H, Kim CS, Kwon DD

PURPOSE: This study aimed to evaluate the clinical efficacy of enzalutamide in chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) patients using real-world data from Korean patients. MATERIALS AND METHODS: We retrospectively reviewed...
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Prognostic significance of lymphovascular invasion in patients with prostate cancer treated with postoperative radiotherapy

Jeong JU, Nam TK, Song JY, Yoon MS, Ahn SJ, Chung WK, Cho IJ, Kim YH, Cho SH, Jung SI, Kwon DD

PURPOSE: To determine prognostic significance of lymphovascular invasion (LVI) in prostate cancer patients who underwent adjuvant or salvage postoperative radiotherapy (PORT) after radical prostatectomy (RP) MATERIALS AND METHODS: A total of...
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Health-Related Quality of Life Changes in Prostate Cancer Patients after Radical Prostatectomy: A Longitudinal Cohort Study

Shin DW, Lee SH, Kim TH, Yun SJ, Nam JK, Jeon SH, Park SC, Jung SI, Park JH, Park J

PURPOSE: Health-related quality of life (HRQOL) information related to radical prostatectomy (RP) is valuable for prostate cancer (PC) patients needing to make treatment decisions. We aimed to investigate HRQOL change...
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Development of a multi-channel NIRS-USG hybrid imaging system for detecting prostate cancer and improving the accuracy of imaging-based diagnosis: a phantom study

Bae H, Kim SS, Lee S, Song H, Lee S, Koh D, Kim JG, Jung DC

PURPOSE: This study aimed to develop a multi-channel near-infrared spectroscopy (NIRS) and ultrasonography (USG) fusion imaging system for imaging prostate cancer and to verify its diagnostic capability by applying the...
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Value of the New 5-Tiered Prostate Cancer Grade Group System on Predicting Oncological Outcomes for Radical Prostatectomy Population in Korea

Cho M, Yoo S, Park J, Jeong CW, Ku JH, Kwak C, Kim HH, Cho MC, Jeong H

PURPOSE: We evaluated the prognostic value of the 5-tiered grade group in Korean patients who underwent radical prostatectomy. MATERIALS AND METHODS: Between 1996 and 2016, a number of 2,883 consecutive patients...
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Effects of Aspirin, Nonsteroidal Anti-inflammatory Drugs, Statin, and COX2 Inhibitor on the Developments of Urological Malignancies: A Population-Based Study with 10-Year Follow-up Data in Korea

Kang M, Ku JH, Kwak C, Kim HH, Jeong CW

PURPOSE: The purpose of this study was to determine the impact of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), statin, and cyclooxygenase 2 (COX-2) inhibitor on the development of kidney, prostate, and...
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Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma

Azizan N, Hayati F, Tizen NM, Farouk WI, Masir N

PURPOSE: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. MATERIALS AND METHODS: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January...
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Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population

Kim SH, Kim S, Joung JY, Kwon WA, Seo HK, Chung J, Nam BH, Lee KH

PURPOSE: The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs....
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Role of Magnetic Resonance Imaging Using Prostate Imaging-Reporting and Data System Version 2 to Predict Clinically Significant Cancer After Radical Prostatectomy in Very Low-Risk or Low-Risk Prostate Cancer

Yoo JH, Song W, Kim TH, Kim CK, Park BK, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Jeon HG

PURPOSE: To determine the negative predictive value (NPV) of multiparametric magnetic resonance imaging (mp-MRI) for clinically significant cancer (CSC) based on the Prostate Imaging-Reporting and Data System (PI-RADS) version 2...
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Chemotherapy With Androgen Deprivation for Hormone-Naïve Prostate Cancer

Jeon BJ, Tae BS, Park JY

Research regarding the treatment of metastatic prostate cancer has been undergoing dramatic progress. Treatment of hormone-naïve metastatic prostate cancer includes surgical castration and medical castration that lowers androgen level in...
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Overdiagnosis in health care: impact of cancer screening

Ahn HS

While overtreatment in medical services has for a long time been a topic of interest among the medical community, the concept of overdiagnosis has recently attracted interest because of the...
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Early dutasteride monotherapy in men with detectable serum prostate-specific antigen levels following radical prostatectomy: A prospective trial

Shin YS, Lee JW, Kim MK, Jeong YB, Park SC

PURPOSE: To investigate the effects of early administration of dutasteride in patients with detectable serum prostate-specific antigen (PSA) levels after radical prostatectomy (RP). MATERIALS AND METHODS: A prospective open-label study, with...
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Outcomes of Active Surveillance in Localized Prostate Cancer

Park H, Kim JH

Active surveillance (AS) is currently accepted as a good management option for men with low-risk prostate cancer (PCa). Moreover, given the grade migration following the 2005 International Society of Urologic...
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