Tuberc Respir Dis.  2000 May;48(5):794-801. 10.4046/trd.2000.48.5.794.

A Case of carbamazepine induced bronchiolitis obliterans organizing pneumonia

• Ok KS
• Park BK
• Kim HS
• Lee HK
• Jin SL
• Jin JY
• Lee HP
• Kim JI
• Choi SJ
• Yum HK

• KMID: 2160233
• DOI: http://doi.org/10.4046/trd.2000.48.5.794

Abstract

BOOP(Bronchiolitis Obliterans Organizing Pneumonia) is an inflammatory reaction that follows damage to the bronchiolar epithelium of the small conducting airways. BOOP is characterized by the pathologic finding of excessive proliferation of granulation tissue within the respiratory bronchioles, alveolar duct and spaces, accompanied by organizing pneumonia. BOOP may result from diverse causes such as toxic fumes, connective tissue disorders, infections, organ transplantation and drugs or appear idiopathically. Drug induced BOOP has been described in association with acebutolol, amiodarone, cephalosporin, bleomycine, tryptophan, gold salts, barbiturates, sulfasalazine, and carbamazepine. Carbamazepine is an iminostilbene derivative that is used as both and anticonvulasnt and pain reliever for pains associated with trigeminal neuralgia. It is structually related to the tricyclic antidepressants. To our knowledge, there have been no previously reported case that has described development of BOOP during carbamazepine treatment in Korea, and only two cases have been reported in the world. We report a case of carbamazepine-induce BOOP with a brief review of literature.

Keyword

BOOP; Carbamazepine; Drug induced BOOP

MeSH Terms

Acebutolol
Amiodarone
Antidepressive Agents, Tricyclic
Barbiturates
Bleomycin
Bronchioles
Bronchiolitis Obliterans*
Bronchiolitis*
Carbamazepine*
Connective Tissue
Cryptogenic Organizing Pneumonia*
Epithelium
Granulation Tissue
Korea
Organ Transplantation
Pneumonia
Salts
Sulfasalazine
Transplants
Trigeminal Neuralgia
Tryptophan
Acebutolol
Amiodarone
Antidepressive Agents, Tricyclic
Barbiturates
Bleomycin
Carbamazepine
Salts
Sulfasalazine
Tryptophan