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Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression

Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q

Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis...
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Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice

Ghafouri Z, Seyyedian , Nikbakht J, Kouhsari E, Bayat S, Zargar H, Houshmand

BACKGROUND/AIMS: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment. METHODS: To assess drugs with...
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Clinical Features and Treatment Patterns of Korean Patients with Psoriatic Arthritis: A Retrospective Single-center Study

Lee M, Lee JW, Kim TG, Lee MG

  • KMID: 2436702
  • Korean J Dermatol.
  • 2018 Jun;56(5):308-313.
BACKGROUND: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis associated with psoriasis. The prevalence of PsA varies across different countries, and a few previous studies have reported that 9~17% of...
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Disease Characteristics and Change in Arthritis Activity according to Treatment in Hepatitis B Surface Antigen-positive Rheumatoid Arthritis Patients: a Retrospective Chart Review Study

Eun Y, Kim IY, Jeong H, Kim H, Lee J, Choi MS, Koh E, Cha HS

BACKGROUND: Rheumatoid arthritis (RA) treatment may differ according to hepatitis B state and consequently may bring about different arthritis outcomes. However, whether hepatitis B affects treatment outcome remains unclear. We...
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Drug Reaction with Eosinophilia and Systemic Symptoms Associated with Reactivation of Epstein-Barr Virus and/or Cytomegalovirus Leading to Hemophagocytic Syndrome in One of Two Patients

Liang J, Qu H, Wang X, Wang A, Liu L, Tu P, Li R, Wang M

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of...
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Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations

Kaplan AP

The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H1-receptor blockers are typically employed up to...
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A Case of Rheumatoid Arthritis accompanied by Organizing Pneumonia Successfully Treated with Prednisolone, Clarithromycin and Tacrolimus

Ohe M

A 74-year-old man suffering from cryptogenic organizing pneumonia (OP) visited our department with arthralgia accompanied with partial swellings of proximal interphalangeal and metacarpophalangeal joints with morning stiffness. A diagnose of...
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Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse

Han KH, Park JM, Jeong M, Han YM, Go EJ, Park J, Kim H, Han JG, Kwon O, Hahm KB

BACKGROUND/AIMS: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes...
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Comparative efficacy of biological agents in methotrexate-refractory rheumatoid arthritis patients: a Bayesian mixed treatment comparison

Choi M, Hyun MK, Choi S, Tchoe HJ, Lee SY, Son KM, Kim MJ, Jung YO, Kim HA

BACKGROUND/AIMS: Biological agents (biologics) targeting proinflammatory signaling have emerged as an important treatment option in rheumatoid arthritis (RA). Despite the clinical effectiveness of biologics for patients with RA who do...
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Assessment of collagen antibody-induced arthritis in BALB/c mice using bioimaging analysis and histopathological examination

Sim JH, Lee WK, Lee YS, Kang JS

The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided...
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Clinical Characteristics of Psoriatic Arthritis among Korean Patients with Psoriasis: A Single Center Experience

Lee HJ, Kim JM, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS

  • KMID: 2382986
  • Korean J Dermatol.
  • 2016 Jun;54(5):329-334.
BACKGROUND: The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis are known to show ethnic variations. However, limited data exist regarding psoriatic arthritis in Korean psoriasis...
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Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis

Kim KM, Sung K, Yang HK, Kim SH, Kim HY, Ban GH, Park SE, Lee HD, Kim SY

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal condition characterized by skin rash, fever, eosinophilia, and multiorgan involvement. Various drugs may be associated...
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Tocilizumab-induced Transaminitis in a Seropositive Rheumatoid Arthritis Patient with Macrophage Activation Syndrome

Yoo BW, Park CK, Yun HR, Kim D, Lee SK, Lee SW

As a new humanized monoclonal antibody against the interleukin-6 receptor, tocilizumab is currently used for the treatment of rheumatoid arthritis (RA) patients. Tocilizumab was reported to provoke drug-related liver toxicity,...
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A Case of Axial Spondyloarthropathy in a Patient with Human Immunodeficiency Virus Infection

Kim TJ, Jeon CH

Human immunodeficiency virus (HIV) infection is a global pandemic affecting more than 2.9 million people. Aside from opportunistic infections and malignancies, it involves multiple organs, resulting in many complications, and...
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A Case of Behcet's Disease with Both Esophageal and Pharyngeal Ulcers Successfully treated with Steroid and Sulfasalazine

Yoon HY, Cho IJ, Lee H, Choi YJ, Lee WS, Yoo WH

Behcet's disease is a heterogeneous disease that involves variable organ systems. Gastrointestinal Behcet's disease is rare and it generally affects the terminal ileum with propagation toward the cecum and ascending...
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Pulmonary Cryptococcosis in Rheumatoid Arthritis Patient Treated With Leflunomide

Byon CK, Yim SW, Park JY, Roh MS, Lee SW, Chung WT, Lee SY

Leflunomide, a disease-modifying antirheumatic drug, is effective for rheumatoid arthritis as monotherapy or combination therapy with methotrexate. The most common adverse effects are diarrhea, dyspepsia, nausea, abdominal pain, oral ulcer,...
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A Case of Sulfasalazine-Induced Hypersensitivity Syndrome Confirmed by Enzyme-Linked Immunospot Assay

Phatharacharukul P, Klaewsongkram J

A 24-year-old male with a history of spondyloarthropathy presented with high fever, cervical lymphadenopathy and generalized maculopapular rash. He was treated with prednisolone for chronic uveitis before being switched to...
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Adalimumab Induced Acute Exacerbation of Rheumatoid Arthritis Related Interstitial Lung Disease

Park WK, Lee YS, Won S, Kim HR, Lee JH, Lee KB, Kim JH

A 69-year-old woman with 6 years history of seropositive rheumatoid arthritis (RA) and asymptomatic interstitial lung disease (ILD) began taking adalimumab for ongoing arthritis despite intakes of sulfasalazine and hydroxychloroquine...
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Updates of Spondyloarthrothy Treatment

Kim TH

The goals of treatment in Spondyloarthropathy are to reduce pain and stiffness, and to maintain good quality of life. Regular exercise with stretching of axial skeleton is most important. No...
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Reactive Arthritis

Park KS

Reactive arthritis (ReA) is an inflammatory joint disease following genitourinary or gastrointestinal bacterial infection, most commonly by Chlamydia trachomatis. It is characterized by the inflammation in the large joints of...
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