J Korean Med Sci.  2013 Jan;28(1):93-99. 10.3346/jkms.2013.28.1.93.

Computational Quantification of the Cardiac Energy Consumption during Intra-Aortic Balloon Pumping Using a Cardiac Electromechanics Model

• Lim KM
• Lee JS
• Gyeong MS
• Choi JS
• Choi SW
• Shim EB

• KMID: 2158007
• DOI: http://doi.org/10.3346/jkms.2013.28.1.93

Abstract

To quantify the reduction in workload during intra-aortic balloon pump (IABP) therapy, indirect parameters are used, such as the mean arterial pressure during diastole, product of heart rate and peak systolic pressure, and pressure-volume area. Therefore, we investigated the cardiac energy consumption during IABP therapy using a cardiac electromechanics model. We incorporated an IABP function into a previously developed electromechanical model of the ventricle with a lumped model of the circulatory system and investigated the cardiac energy consumption at different IABP inflation volumes. When the IABP was used at inflation level 5, the cardiac output and stroke volume increased 11%, the ejection fraction increased 21%, the stroke work decreased 1%, the mean arterial pressure increased 10%, and the ATP consumption decreased 12%. These results show that although the ATP consumption is decreased significantly, stroke work is decreased only slightly, which indicates that the IABP helps the failed ventricle to pump blood efficiently.

Keyword

Intra-Aortic Balloon Pump; Cardiac Electromechanics Model; ATP Consumption; Stroke Work

MeSH Terms

Adenosine Triphosphate/*metabolism
Arterial Pressure
Cardiac Output
Heart Failure/pathology
Heart Rate
Humans
*Intra-Aortic Balloon Pumping
*Models, Theoretical
Stroke Volume
Ventricular Function, Left
Adenosine Triphosphate