J Korean Med Sci.  2015 Jan;30(1):110-114. 10.3346/jkms.2015.30.1.110.

Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report

Affiliations
  • 1Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. shinehr@gmail.com
  • 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.

Keyword

Acute Kidney Injury; Megalocytic Interstitial Nephritis; Interstitial Nephritis

MeSH Terms

Acute Disease
Acute Kidney Injury/complications/*drug therapy/pathology
Anti-Bacterial Agents/therapeutic use
Azithromycin/therapeutic use
Bacteremia/*drug therapy/microbiology/pathology
Cefotaxime/therapeutic use
Creatinine/blood
Escherichia coli
Escherichia coli Infections/*drug therapy/microbiology/pathology
Female
Humans
Kidney/pathology
Methylprednisolone/therapeutic use
Middle Aged
Nephritis, Interstitial/*drug therapy/immunology/pathology
Pyelonephritis/complications/*drug therapy/pathology
Renal Dialysis
Shock, Septic/drug therapy/microbiology
Anti-Bacterial Agents
Azithromycin
Cefotaxime
Creatinine
Methylprednisolone

Figure

  • Fig. 1 Features of the renal biopsy. (A) Under light microscopy (×200), the mesangial matrix was mildly increased and the interstitium was multifocally infiltrated by histiocytic collection. (B) Tubules revealed diffuse acute damage and minimal atrophy accompanied by mild interstitial fibrosis. Immunohistochemistry studies showed CD68 positivity in infiltrated histiocytes. But stain for iron and calcium were negative. (C) Using immunofluorescence microscopy (×400), mesangial staining was positive for C1q (2+). (D) Electron microscopy showed moderate effacement of epithelial foot processes. The mesangial matrix is moderately increased with a few electron dense deposits.

  • Fig. 2 Change in serum creatinine level (A), WBC count (B), and clinical course during hospitalization. After administration of methylprednisolone 1 mg/kg for megalocytic interstitial nephritis and severe HLH on the 38th hospital day, both oliguric AKI and severe leukocytosis were dramatically improved. S-M, Solu-Medrol® (methylprednisolone sodium succinate); BM, bone marrow.


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