Yeungnam Univ J Med.  1998 Jun;15(1):36-46. 10.12701/yujm.1998.15.1.36.

A Clinicopathological Study of Solid and Papillary Neoplasm of Pancreas

• Choi JH
• Gu MJ
• Kim HJ

• KMID: 2154410
• DOI: http://doi.org/10.12701/yujm.1998.15.1.36

Abstract

Solid and papillary epithelial neoplasm of pancreas is a rare tumor, usually affecting young women, and its histogenesis is still controversial. This study was performed to define the clinicopathologic features and cellular origin of this tumor. Eight female cases of solid and papillary epithelial neoplasm of pancreas were studied by analyzing the clinicopathologic findings and immunohistochemical and electron-microscopic findings. The age of eight cases ranged from 21 to 54 years (mean, 34 years). The tumors developed in the tail (4 cases), body-tail (2 cases), body (1 case) and head (1 case). The mean diameter of tumors was 9.3 cm (range, 5.5 to 13 cm). Tumors showed solid, cystic and hemorrhagic areas. Histologically, the tumor cells were uniformly round or polygonal in shape, and formed solid sheets and papillary pattern. On the immunohistochemical stain, 8 cases (100%) were immunoreactive for alpha1-antitrypsin, 7 cases (87.5%) for cytokeratin, 7 cases (87.5%) for progesterone receptor, 6 cases (75%) for vimentin, and 1 case (12.5%) for synaptophysin, respectively. None of them were immunoreactive for estrogen receptor. Electron microscopic examination showed many mitochondria, annulate lamellae and canaliculi-like gap. These findings suggest that solid and papillary epithelial tumor of pancreas possibly originates from totipotential stem cells.

Keyword

Solid and papillary epithelial neoplasm of pancreas; Immunohistochemistry; Ultrastructure

MeSH Terms

Estrogens
Female
Head
Humans
Immunohistochemistry
Keratins
Mitochondria
Neoplasms, Glandular and Epithelial
Pancreas*
Receptors, Progesterone
Stem Cells
Synaptophysin
Vimentin
Estrogens
Keratins
Receptors, Progesterone
Synaptophysin
Vimentin