Korean J Anesthesiol.  2015 Aug;68(4):364-372. 10.4097/kjae.2015.68.4.364.

Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial

• Shin HJ
• Na HS
• Jeon YT
• Lee GW
• Do SH

• KMID: 2152879
• DOI: http://doi.org/10.4097/kjae.2015.68.4.364

Abstract

BACKGROUND
Hydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES.
METHODS
Patients were randomized to receive volume replacement with 10% pentastarch 260/0.45 in 0.9% saline (Group-PEN, n = 25), 6% tetrastarch 130/0.4 in 0.9% saline (Group-TET(S), n = 25), or 6% tetrastarch 130/0.4 in a balanced electrolyte solution (Group-TET(B), n = 25). Coagulation was assessed using rotational thromboelastometry (ROTEM(R)) and other laboratory tests were performed, including measurements of hematological and hemostatic parameters and electrolytes.
RESULTS
Post-operative ROTEM(R) parameters changed toward hypocoagulable states in all groups. The post-operative parameters of EXTEM and FIBTEM were more impaired in Group-PEN than in Group-TET(B). The percentage change in INTEM clot formation time (P = 0.004) and alpha-angle (P = 0.003) were smaller in Group-TET(S) and Group-TET(B) than in Group-PEN. The percentage change in the FIBTEM maximum clot firmness was greatest in Group-PEN (P = 0.011). The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TET(B).
CONCLUSIONS
The 6% HES 130/0.4 in a balanced electrolyte solution seemed to have less of an impact on blood coagulation than the 10% HES 260/0.45. No differences in hemostatic profile were observed between the balanced electrolyte and saline-based 6% HES 130/0.4.

Keyword

Blood coagulation; Hydroxyethyl starch; Rotational thromboelastometry

MeSH Terms

Arthroplasty, Replacement, Hip*
Blood Coagulation*
Colloids*
Electrolytes
Humans
Hydroxyethyl Starch Derivatives*
Hypovolemia
International Normalized Ratio
Partial Thromboplastin Time
Plasma
Prothrombin Time
Starch
Thrombelastography
Colloids
Electrolytes
Hydroxyethyl Starch Derivatives
Starch