Anesth Pain Med.  2010 Oct;5(4):355-359.

The effect of administering colloid solution on the postoperative blood loss in patients who are undergoing total knee arthroplasty: Comparing Hextend with Voluven

• Kim JY
• Kim JS
• Han SG
• Park KS
• Hwang JH
• Park SY

Abstract

BACKGROUND
Total knee arthroplasty (TKR) is associated with a significant loss of blood. Fluid substitution with crystalloid or colloid solutions to correct perioperative hypovolemia is essential. Colloid solutions, and especially hydroxyethyl starches (HES), are used to treat hypovolemia, but they may affect blood coagulation. The purpose of this study was to test the efficacy and the safety of colloid solutions in patients undergoing TKR.
METHODS
The patients undergoing TKR were divided into a group that underwent fluid management with Voluven(R) (n = 22) and a group that was managed with Hextend(R) (n = 24). The blood loss, the autotransfused blood volume, the hemoglobin level, the allogenic blood requirement, the urine output and the complications were assessed.
RESULTS
There were no significant differences in the amount of blood loss, the autotransfused blood volume, the allogenic requirement, the urine output and the complications between the two groups.
CONCLUSIONS
Voluven(R) and Hextend(R) are equally efficacious plasma volume substitutes when performing TKR with an autotransfusion of drained blood.

Keyword

Colloid solution; Hydroxyethyl starch; Total knee arthroplasty

MeSH Terms

Arthroplasty
Blood Coagulation
Blood Transfusion, Autologous
Blood Volume
Colloids
Hemoglobins
Hetastarch
Humans
Hypovolemia
Isotonic Solutions
Knee
Plasma Volume
Postoperative Hemorrhage
Colloids
Hemoglobins
Hetastarch
Isotonic Solutions