Immune Netw.  2014 Aug;14(4):182-186. 10.4110/in.2014.14.4.182.

Interplay between Inflammatory Responses and Lymphatic Vessels

• Shin K
• Lee SH

• KMID: 2150806
• DOI: http://doi.org/10.4110/in.2014.14.4.182

Abstract

Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.

Keyword

Lymphangiogenesis; Lymphatic vessels; Inflammation; Immune responses

MeSH Terms

Cytokines
Drainage
Emigration and Immigration
Endothelial Cells
Inflammation
Leukocytes
Lymphangiogenesis
Lymphatic Vessels*
Cytokines

Figure

• 

  Figure 1 The lymphangiogenic balance between pro-lymphangiogenic factors and anti-lymphangiogenic factors regulates lymphatic vascular homeostasis. Lymphangiogenesis under pathophysiological conditions is associated with increased pro-lymphangiogenic factors and/or decreased anti-lymphangiogenic factors.

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