Immune Netw.  2013 Aug;13(4):111-115. 10.4110/in.2013.13.4.111.

Osteoimmunology: A Brief Introduction

• Greenblatt MB
• Shim JH

• KMID: 2150775
• DOI: http://doi.org/10.4110/in.2013.13.4.111

Abstract

Recent investigations have demonstrated extensive reciprocal interactions between the immune and skeletal systems, resulting in the establishment of osteoimmunology as a cross-disciplinary field. Here we highlight core concepts and recent advances in this emerging area of study.

Keyword

Osteoimmunology; Bone; Osteoblasts; T cells; Cytokines

MeSH Terms

Cytokines
Osteoblasts
T-Lymphocytes
Cytokines

Figure

• 

  Figure 1 A schematic depicting major pathways of interactions between the immune system and bone, highlighting in particular the effects of TNF, IL-1, IL-6, and IL-17 on the promotion of bone resorption. Additionally, anti-osteoclastogenic effects of IFN-γ are depicted.

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