Immune Netw.  2009 Jun;9(3):75-83. 10.4110/in.2009.9.3.75.

The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function

• Koretzky G

• KMID: 2150645
• DOI: http://doi.org/10.4110/in.2009.9.3.75

Abstract

Recent years have seen an explosion of new knowledge defining the molecular events that are critical for development and activation of immune cells. Much of this new information has come from a careful molecular dissection of key signal transduction pathways that are initiated when immune cell receptors are engaged. In addition to the receptors themselves and critical effector molecules, these signaling pathways depend on adapters, proteins that have no intrinsic effector function but serve instead as scaffolds to nucleate multimolecular complexes. This review summarizes some of what has been learned about one such adapter protein, SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76), and how it regulates and integrates signals after engagement of immunoreceptors and integrins on various immune cell lineages.

Keyword

SH2 domain-containing leukocyte phosphoprotein of 76 kDa; signal transduction; T cells; integrins; immunoreceptors; adapter proteins

MeSH Terms

Explosions
Integrins
Leukocytes
Proteins
Signal Transduction
T-Lymphocytes
Integrins
Proteins

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