Kosin Med J.  2015 Dec;30(2):103-107. 10.7180/kmj.2015.30.2.103.

Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells

• Hwang SY
• Kim TH
• Lee HH
• Kim HY
• Seo J

• KMID: 2150495
• DOI: http://doi.org/10.7180/kmj.2015.30.2.103

Abstract

Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.

Keyword

Apoptosis; breast neoplasms; docosahexaenoic acid; metastasis; proliferation

MeSH Terms

Apoptosis
Breast Neoplasms*
Breast*
Caspase 8
Caspase 9
Cell Line
Lipid Peroxidation
MCF-7 Cells
Neoplasm Metastasis
Reactive Oxygen Species
Caspase 8
Caspase 9
Reactive Oxygen Species

Reference

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