Korean J Helicobacter Up Gastrointest Res.  2015 Dec;15(4):222-224. 10.7704/kjhugr.2015.15.4.222.

Current Strategies for Eradication of Helicobacter pylori in Korea

• Tae CH
• Shim KN

• KMID: 2149701
• DOI: http://doi.org/10.7704/kjhugr.2015.15.4.222

Abstract

Since the development of guidelines for the diagnosis and treatment of Helicobacter pylori infection in 1998, the Korean College of Helicobacter and Upper Gastrointestinal Research proposed revised guidelines in 2009 and 2013. The revised guideline in 2013 recommends triple therapy including conventional proton pump inhibitor (PPI), clarithromycin, and amoxicillin for 7 days as the primary eradication regimen. When clarithromycin resistance is suspected, quadruple therapy including PPI, metronidazole, bismuth, and tetracycline for 7~14 days is recommended as an alternative primary regimen for H. pylori eradication. Bismuth-containing quadruple therapy is recommended in cases of H. pylori eradication failure when the initial treatment was triple therapy. When initial bismuth-containing quadruple therapy fails to eradicate H. pylori, it is very difficult to create a secondary regimen. There is paucity of evidence regarding these secondary regimens. In addition, due to the declining eradication rates of primary regimens in recent years, other potential combinations including sequential and concomitant therapies have been considered.

Keyword

Helicobacter pylori; Eradication; Guideline

MeSH Terms

Amoxicillin
Bismuth
Clarithromycin
Diagnosis
Helicobacter pylori*
Helicobacter*
Korea*
Metronidazole
Proton Pumps
Tetracycline
Amoxicillin
Bismuth
Clarithromycin
Metronidazole
Proton Pumps
Tetracycline