J Korean Orthop Res Soc.  2015 Jun;18(1):9-17. 10.0000/jkors.2015.18.1.9.

Surface Characteristics and Biocompatibility of Micro Arc Oxidized Titanium Alloy

• Lim YW
• Lee ES
• Kim YS
• Song KY
• Kwon SY

• KMID: 2149633
• DOI: http://doi.org/10.0000/jkors.2015.18.1.9

Abstract

PURPOSE
The aim of this research was to characterize micro arc oxidized titanium (MAO-Ti), accompanied by biocompatibility test in vivo as well as in vitro in comparison to the different types of surface modification; machined, blasted and plasma spray.
MATERIALS AND METHODS
XRD and SEM investigations were performed in order to assess the structure and morphology. Biologic and morphologic responses to the osteoblast cell lines (Saos-2) were then examined, using Promeg(R) proliferation assay, alkalinephosphatase activity, alphavbeta3 integrin expression and cytoskeleton staining (Rhodamine-Phallodine). The analysis of gene expression for osteocalcin and collagen I was done through RT-PCR.
RESULTS
MAO-Ti showed more activity on osteointegration and cell differentiation compared to other types of surface modification.
CONCLUSION
In summary, MAO-Ti appears to exhibit more favorable biocompatibility than the compared groups in vitro and in vivo as well.

Keyword

Micro Arc Oxidized (MAO); Biocompatibility; Titanium Alloy

MeSH Terms

Alloys*
Cell Differentiation
Cell Line
Collagen
Cytoskeleton
Gene Expression
Osteoblasts
Osteocalcin
Plasma
Titanium*
Alloys
Collagen
Osteocalcin
Titanium