Korean J Anesthesiol.  1993 Jun;26(3):426-433. 10.4097/kjae.1993.26.3.426.

The Effect of Pentaspan on The Vascular Tone of The Isolated Rat Abdominal Aorta and Renal Artery

• Suh JK
• Kim JW
• Jun JH
• Shim JC
• Kim KH
• Lee DH
• Kim KS
• Yoo HK
• Seung IS
• Chon SU

• KMID: 2145912
• DOI: http://doi.org/10.4097/kjae.1993.26.3.426

Abstract

The Pentaspan is a high molecular weight(250,000), hyperosmolar(320 mOsm/l) colloid solution and blood volume expander in clinical practice. Many researches revealed the decreasing of systemic vascular resistance and pulmonary vascular resistance after Pentaspan administration in vivo. Some colloid solution is contraindicated in acute renal failure. We tried to confirm the direct effects of the Pentaspan and its mechanism on the abdominal aorta and renal artery in vitro. The rat abdominal aorta and renal artery were precontracted with norepinephrine(10(-7) M/1) in 50 ml Krebs solution and 5 ml Pentaspan was infused. Ten mininutes after, changes of the vascular tones were obtained. The results were as follows. 1) The vascular tones were significantly decreased in both vessels. 2) Abdominal aorta group, renal artery group and with or without endothelium group were not significant different each other. 3) The vascular tones were not affected by with or without endothelium, indomethacin and methylene blue pretreatment. Smooth muscles were induced relaxation by the Pentaspan infusion and the relaxation were not dependent to endothelium derived relaxing factor, prostanoid and cyclic guanosinemonophosphate.

Keyword

Artery; abdominal aorta; renal artery; Endothelium; Smooth Muscle; vascular Pharmacology Pentaspan; indomethacin; methylene blue; prostanoid; cyclic guanosinemonophosphate

MeSH Terms

Acute Kidney Injury
Animals
Aorta, Abdominal*
Arteries
Blood Volume
Colloids
Endothelium
Endothelium-Dependent Relaxing Factors
Hydroxyethyl Starch Derivatives*
Indomethacin
Methylene Blue
Muscle, Smooth
Rats*
Relaxation
Renal Artery*
Vascular Resistance
Colloids
Endothelium-Dependent Relaxing Factors
Hydroxyethyl Starch Derivatives
Indomethacin
Methylene Blue