Korean J Hematol.
2002 Nov;37(4):282-286.
Report of Two Patients with Severe Aplastic Anemia Who Showed Trilineage Hematologic Response to Low-dose Erythropoietin
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University, School of Medicine, Daegu, Korea. sksohn@knu.ac.kr
- 2Cancer Research Institute, Kyungpook National University, School of Medicine, Daegu, Korea.
Abstract
- Aplastic anemia is characterized by multilineage bone marrow failure resulting in pancytopenia. There is no effective therapy for patients with severe aplastic anemia who were refractory to immunosuppresive therapy including antithymocyte globulin (ATG) or relapsed after allogeneic bone marrow transplantation. We report hereby that two patients with severe aplastic anemia who were relapsed after immu-nosuppresive therapy with ATG and cyclosporine A were successfully treated with low dose erythropoietin. Observed trilineage hematologic response was dependent on low dose erythropoietin therapy.
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