Korean J Pediatr.  2006 Apr;49(4):455-459. 10.3345/kjp.2006.49.4.455.

A case of acute respiratory distress syndrome treated with surfactant and low dose methylprednisolone

• Choi BY
• Kim KM
• Yoon JS
• Lee JS

• KMID: 2140914
• DOI: http://doi.org/10.3345/kjp.2006.49.4.455

Abstract

The major pathogenesis of acute respiratory distress syndrome (ARDS) is an inflammatory process that results from a diversity of injuries to the body. Due to the various cytokines and vasoactive peptides released from the endothelium, the vascular permeability is increased; the migration of inflammatory cells and the leakage of plasma proteins then occur and edema develops in the alveolus. There is a hypothesis that the impairment of alveolar recruitment in ARDS is caused by a defect of the surfactant system and the resultant increase of alveolar surface tension. This has been studied in pediatric patients in ARDS; after the administration of surfactant, hypoxia, respiratory symptoms and survival chances were improved. To alleviate the major pathogenic mechanism in this disease, that is to say, inflammation of the lung, steroids have been used and studied as another treatment modality for ARDS, and it has been concluded that the administration of low dose methylprednisolone may improve patients' symptoms and survival rates. We report here on a case of a young infant admitted with ARDS, who, after the intratracheal administration of 120 mg/kg surfactant, on PaO(2)/FiO(2) was elevated. Subsequent low doses of methylprednisolone were given, and the symptoms did not recur, and no fibrotic change was shown during the follow-up period of 2 months.

Keyword

Acute respiratory distress syndrome; Surfactant; MethylprednisoloneIntroduction

MeSH Terms

Anoxia
Blood Proteins
Capillary Permeability
Cytokines
Edema
Endothelium
Follow-Up Studies
Humans
Infant
Inflammation
Lung
Methylprednisolone*
Peptides
Respiratory Distress Syndrome, Adult*
Steroids
Surface Tension
Survival Rate
Blood Proteins
Cytokines
Methylprednisolone
Peptides
Steroids