Korean J Pediatr.  2006 Jul;49(7):718-725. 10.3345/kjp.2006.49.7.718.

Update in the etiology and treatment of sexual precocity

• Park MJ

• KMID: 2140883
• DOI: http://doi.org/10.3345/kjp.2006.49.7.718

Abstract

The pubertal activation of gonadotrophin releasing hormone(GnRH) requires coordinated changes in excitatory or inhibitory amino acids, growth factors, and a group of transcriptional regulators. The age of onset of puberty is progressing to younger age. Factors affecting early puberty include genetic traits, nutrition(body fat) and exposure to endocrine disrupting chemicals. In rapidly progressing central precocious puberty, gonadotrophin releasing hormone(GnRH) agonists(GnRHa) appear to increase final height if treated early stage. Further large scaled long-term follow-up study of the effects of GnRHa on final height is needed.

Keyword

Puberty; Sexual precocity; Endocrine disrupting chemicals(EDC); Gonadotrophin releasing hormone agonists(GnRHa); Final height

MeSH Terms

Adolescent
Age of Onset
Amino Acids
Endocrine Disruptors
Humans
Intercellular Signaling Peptides and Proteins
Puberty
Puberty, Precocious
Amino Acids
Endocrine Disruptors
Intercellular Signaling Peptides and Proteins