Korean J Pediatr.  2007 Apr;50(4):386-389. 10.3345/kjp.2007.50.4.386.

Topiramate can reduce the number of episodic attacks in cyclic vomiting syndrome:a case report

• Yum MS
• Bae KW
• You SJ
• Ko TS

• KMID: 2140835
• DOI: http://doi.org/10.3345/kjp.2007.50.4.386

Abstract

Cyclic vomiting syndrome (CVS) is a paroxysmal, recurrent vomiting disorder of unknown pathophysiology and target organ. It has been hypothesized that CVS shares the same mechanism as migraine. We describe here a 5-year-old boy with CVS characterized by episodic vomiting attacks. These recurrent vomiting episodes began at 3 years of age, occurred every month and lasted for 5 days at a time. At the time of admission, no abnormal physical or neurological findings were observed and laboratory findings, including brain MRI and endoscopic examination, revealed nothing specific. The vomiting episodes were self-limited but recurrent and severely interrupted his daily life. When this patient was treated with topiramate, he showed a marked increase of symptom-free periods.

Keyword

Vomiting; Topiramate; Migraine; Child

MeSH Terms

Brain
Child
Child, Preschool
Humans
Magnetic Resonance Imaging
Male
Migraine Disorders
Vomiting*