J Korean Cancer Assoc.  2000 Feb;32(1):86-92.

Combination Chemotherapy with VP - 16 , Ifosfamide , and Cisplatin ( VIP ) in the Advanced Non - Small Cell Lung Cancer

• Cho YS
• Kim SY
• Kim JH
• Yoon HJ
• Cho KS

Abstract

PURPOSE: We conducted a phase II study in previously untreated patients with unresectable stage IIIB or IV non-small cell lung cancer to evaluate the response rate and toxicity of the combination chemotherapy regimen of etoposide, ifosfamide and cisplatin.
MATERIALS AND METHODS
From September 1993 to December 1996, twenty patients with advanced non-small cell lung cancer (stage IIIB 5 and IV 15) (squamous cell 8, adeno- carcinoma 12), were enrolled in this study. There were 13 (65%) males and 7 (35%) females, and median age of patients were 56 years (range: 34~66). Eighteen patients had performance status (ECOG) 0~1, two patients had performance status 2. Treatment was consisted of cisplatin (20 mg/m2 i.v., day 1~4), VP-16 (etoposide) (75 mg/m2 i.v., day 1~4), ifosfamide (1000 mg/m2 i.v., day 1~4) with mesna. This treatment was repeated every four weeks.
RESULTS
The overall response rate was 25%. Complete response rate was 5% (1/20) and partial response rate was 20% (4/20). The median cycle of response was 4 (2~6) cycles. The median overall survival time was 28 weeks (9~98 weeks). The median time to progression was 10 weeks (3~50 weeks). Toxicities were evaluated by WHO criteria. Toxicity > GradeIII included: leukopenia 1.6%, thrombocytopenia 3.2%, nausea and vomiting 15%, alopecia 30%, stomatitis 10%. These toxicities were tolerable and reversible.
CONCLUSION
VIP regimen was not superior to previous regimens for advanced non-small all lung cancer, and the toxicities were tolerable.

Keyword

Non-small-cell lung cancer; Combination chemotherapy; Cisplatin; Etoposide; Ifosfamide

MeSH Terms

Alopecia
Carcinoma, Non-Small-Cell Lung
Cisplatin*
Drug Therapy, Combination*
Etoposide
Female
Humans
Ifosfamide*
Leukopenia
Lung Neoplasms
Male
Mesna
Nausea
Small Cell Lung Carcinoma*
Stomatitis
Thrombocytopenia
Vomiting
Cisplatin
Etoposide
Ifosfamide
Mesna