J Bacteriol Virol.  2014 Mar;44(1):44-51. 10.4167/jbv.2014.44.1.44.

Comparisons of CTX-M-Producing Escherichia coli Isolates from Humans and Animals in South Korea

Affiliations
  • 1Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea. ksko@skku.edu
  • 2Animal, Plant and Fisheries Qurantine and Inspection Agency, Anyang, Korea.
  • 3Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea.

Abstract

To investigate the possibility of transmission of CTX-M-producing Escherichia coli isolates among humans and animals, we compared CTX-M-producing E. coli isolates showing the same genotype from humans and dogs in Korea. Sixteen CTX-M-producing E. coli isolates from animals were selected and their genotypes were identified using MLST. Among clinical CTX-M-producing E. coli isolates from humans, which have been identified in previous studies, 12 isolates showing the same STs with those of E. coli isolates from animals were selected. For these 28 CTX-M-producing E. coli isolates, identification of bla CTX-M genes and their genetic environments, antimicrobial susceptibility testing, extended MLST, and PFGE were performed. Some CTX-M-producing E. coli isolates from humans showed the same genotypes, such as ST10, ST38, ST58, and ST95, but different CTX-M enzymes and PFGE patterns. Thus, it can be concluded that dissemination of ESBL-producing E. coli isolates between humans and animals is rare so far.

Keyword

Escherichia coli; Extended spectrum beta-lactamase; CTX-M-type; Transmission

MeSH Terms

Animals*
Dogs
Escherichia coli*
Escherichia*
Genotype
Humans*
Korea*
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