Clin Pediatr Hematol Oncol.
2006 Oct;13(2):150-157.
Clinical Significance of Fc gamma RIIIa Polymorphism in Idiopathic Thrombocytopenic Purpura
- Affiliations
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- 1Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea. khm9210@yonsei.ac.kr
- 2Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 3Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
- 4Department of Pediatrics, Pohang Surin Hospital, Handong University College of Medicine, Pohang, Korea.
- 5Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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PURPOSE: The Fc gammar RIIa receptor, one of the low-affinity immunoglobulin (Ig) receptors, plays an important role in the clearance of autoantibody-sensitized platelets, which is one of the major pathogenetic mechanisms of idiopathic thrombocytopenic purpura (ITP). The polymorphism of Fc gamma RIIIa receptors affects the binding affinity of the receptors to the Fc portion of IgG. The purpose of this study is to find out the clinical significance of Fc gamma RIIIa gene polymorphism in ITP.
METHODS
The genomic DNA was extracted from whole blood of 44 ITP patients and 28 healthy control subjects. The allele specific polymerase chain reaction (PCR) was performed for the Fc gamma RIIIa-176V/F polymorphism determination. The clinical significance of Fc gamma RIIIa genotypes were analysed.
RESULTS
There were no significant difference in the platelet count, hemoglobin level and white blood cell count between acute and chronic ITP patients at initial presentation. The frequency of FF, FV, VV polymorphisms were 9, 14, 5 cases in control group, 10, 3, 0 cases in acute ITP, and 14, 28, 2 cases in chronic ITP, respectively. The frequency of FF polymorphism was higher in acute ITP than in control group or chronic ITP (P<0.05). The acute ITP patients with FV polymorphism tend to respond earlier to less dosage of IVIG without statistical significance. All of the 2 chronic ITP cases with VV polymorphism did not respond to ordinary treatment like steroid or IVIG.
CONCLUSION
The limitation of this study is the small sample size. Further study is needed with more patient in the future.
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