Allergy Asthma Immunol Res.  2010 Jul;2(3):183-187. 10.4168/aair.2010.2.3.183.

The Role of Oxidative Stress in the Pathogenesis of Asthma

• Cho YS
• Moon HB

• KMID: 2133806
• DOI: http://doi.org/10.4168/aair.2010.2.3.183

Abstract

Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the development of immunity, rather than immune tolerance and progression of airway inflammation, is induced. In this article, we suggest that protein tyrosine phosphatases, as intracellular negative regulators, and intracellular antioxidant enzymes such as peroxiredoxins can be regulated by oxidative stress during intracellular signaling.

Keyword

Oxidative stress; asthma; protein tyrosine phosphatases; antioxidants; immune tolerance; airway inflammation; allergy

MeSH Terms

Antioxidants
Asthma
Hypersensitivity
Immune Tolerance
Inflammation
Oxidative Stress
Peroxiredoxins
Protein Tyrosine Phosphatases
Antioxidants
Peroxiredoxins
Protein Tyrosine Phosphatases

Figure

• 

  Figure Results of properly controlled oxidative stress and consequences of inadequately controlled intracellular oxidative stress in the pathogenesis of asthma.

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