Allergy Asthma Immunol Res.  2009 Oct;1(1):36-40. 10.4168/aair.2009.1.1.36.

No evidence of association between interleukin-13 gene polymorphism in aspirin intolerant chronic urticaria

Affiliations
  • 1Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr

Abstract

Aspirin-intolerant chronic urticaria (AICU) is a common condition among the chronic urticaria population, but the genetic mechanism is not yet understood. In this study, the genotypes and haplotypes of three interleukin (IL)-13 polymorphisms, -1510 A>C, -1055C>T, and Arg110Gln (110G>A), as well as their respective clinical phenotypes were examined to determine whether genetic variants of IL-13 play a role in AICU. Single-nucleotide polymorphism (SNP) genotyping was used to compare IL-13 genotype and allele frequencies among 135 patients with AICU, 146 with aspirin-tolerant chronic urticaria (ATCU), and 430 normal controls (NC). Relationships among the AICU phenotype, atopy, and total IgE level were also investigated. The results failed to show a significant difference in the allele or genotype frequencies between the AICU group and either the ATCU or NC group (P>0.05, respectively). Haplotype analysis confirmed that there was no significant difference among the three study groups (P>0.05), nor was there a significant difference in atopy or total IgE level according to the three genetic polymorphisms (P>0.05, respectively). Our data lead to the conclusion that there is no evidence supporting genetic polymorphisms in IL-13 as a genetic risk factor for the development of AICU.

Keyword

aspirin; IL-13; urticaria

MeSH Terms

Alleles
Aspirin
Gene Frequency
Genotype
Haplotypes
Humans
Immunoglobulin E
Interleukin-13
Interleukins
Phenotype
Polymorphism, Genetic
Risk Factors
Urticaria
Aspirin
Immunoglobulin E
Interleukin-13
Interleukins
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