Yonsei Med J.  2007 Dec;48(6):1079-1081. 10.3349/ymj.2007.48.6.1079.

Association of beta2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin-Intolerant Acute Urticaria

  • 1Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr


The genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the beta2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria (AICU), and 498 normal healthy controls (NC) based on a Korean population were enrolled. The genotype of ADRB2 at 46 A > G was analyzed using a direct sequencing method. The ADRB2 polymorphism at 46 A > G showed a significant difference between AIAU and NC; the frequency of the major genotype was significantly higher in the AIAU group (p= 0.017 in recessive model), while no differences were noted in allele and genotype frequencies between AICU and NC. In conclusion, the ADRB2 (46 A > G) gene polymorphism may contribute to the development of the phenotype of AIAU.


ADRB2 polymorphism; aspirin sensitivity; urticaria

MeSH Terms

Aspirin/*adverse effects
Gene Frequency
Middle Aged
*Polymorphism, Single Nucleotide
Receptors, Adrenergic, beta-2/*genetics
Urticaria/chemically induced/*genetics/pathology


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