Yonsei Med J.  2007 Dec;48(6):1079-1081. 10.3349/ymj.2007.48.6.1079.

Association of beta2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin-Intolerant Acute Urticaria

Affiliations
  • 1Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr

Abstract

The genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the beta2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria (AICU), and 498 normal healthy controls (NC) based on a Korean population were enrolled. The genotype of ADRB2 at 46 A > G was analyzed using a direct sequencing method. The ADRB2 polymorphism at 46 A > G showed a significant difference between AIAU and NC; the frequency of the major genotype was significantly higher in the AIAU group (p= 0.017 in recessive model), while no differences were noted in allele and genotype frequencies between AICU and NC. In conclusion, the ADRB2 (46 A > G) gene polymorphism may contribute to the development of the phenotype of AIAU.

Keyword

ADRB2 polymorphism; aspirin sensitivity; urticaria

MeSH Terms

Adult
Aspirin/*adverse effects
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Phenotype
*Polymorphism, Single Nucleotide
Receptors, Adrenergic, beta-2/*genetics
Urticaria/chemically induced/*genetics/pathology

Reference

1. Grattan CE. Aspirin sensitivity and urticaria. Clin Exp Dermatol. 2003. 28:123–127.
2. Kim SH, Park HS. Genetic markers for differentiating aspirin-hypersensitivity. Yonsei Med J. 2006. 47:15–21.
3. Settipane RA, Constantine HP, Settipane GA. Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review. Allergy. 1980. 35:149–154.
4. Mastalerz L, Setkowicz M, Sanak M, Szczeklik A. Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma. J Allergy Clin Immunol. 2004. 113:771–775.
5. Kay LJ, Peachell PT. Mast cell beta2-adrenoceptors. Chem Immunol Allergy. 2005. 87:145–153.
6. Kim SH, Choi JH, Holloway JW, Suh CH, Nahm DH, Ha EH, et al. Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirinintolerant asthma: differing contributions of ALOX5 polymorphism in Korean population. J Korean Med Sci. 2005. 20:926–931.
7. Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JP. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol. 2005. 115:963–972.
8. Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, et al. Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol. 2005. 162:201–211.
9. Hughes JM, Seale JP, Temple DM. Effect of fenoterol on immunological release of leukotrienes and histamine from human lung in vitro: selective antagonism by beta-adrenoceptor antagonists. Eur J Pharmacol. 1983. 95:239–245.
10. Undem BJ, Peachell PT, Lichtenstein LM. Isoproterenolinduced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. J Pharmacol Exp Ther. 1988. 247:209–217.
11. Chong LK, Suvarna K, Chess-Williams R, Peachell PT. Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells. Br J Pharmacol. 2003. 138:512–520.
12. Chong LK, Chowdry J, Ghahramani P, Peachell PT. Influence of genetic polymorphisms in the beta2-adrenoceptor on desensitization in human lung mast cells. Pharmacogenetics. 2000. 10:153–162.
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