Tuberc Respir Dis.  2004 Dec;57(6):594-598. 10.4046/trd.2004.57.6.594.

A Case of Primary Signet Ring Cell Carcinoma of Lung with Multiple Bone Metastasis

• Shin DH
• Kim HI
• Lim SK
• Lee SW
• Jung YM
• Choi YI
• Sheen SS
• Park JH
• Oh YJ
• Park KJ
• Hwang SC
• Park RW
• Shim C

• KMID: 2133010
• DOI: http://doi.org/10.4046/trd.2004.57.6.594

Abstract

Signet ring cell carcinoma of lung is an unique variant of mucin producing adenocarcinoma which is characterized by abundant intracellular mucin accumulation. Only a few cases of primary signet ring cell carcinoma of lung have been reported in the world wide literature. And we have, recently experienced one case of primary signet ring cell carcinoma of lung. A 55 years old man was evaluated for paralysis of lower extremities and was found to have lung cancer in the left upper and lower lobe with pleural, multiple spinal, bone and liver metastases. Signet ring tumor cells were revealed by cytologic examination of pleural fluids. And there were no evidence of signet ring cell carcinoma of other organs. Primary signet ring cell carcinoma of lung seems to have an aggressive behavior and therapeutic modalities could be different from those for signet ring cell carcinomas from other organs. Therefore it is important to separate primary signet ring cell adenocarcinoma of lung from metastatic tumors.

Keyword

Signet ring cell carcinoma; Lung cancer

MeSH Terms

Adenocarcinoma
Carcinoma, Signet Ring Cell*
Humans
Liver
Lower Extremity
Lung Neoplasms
Lung*
Middle Aged
Mucins
Neoplasm Metastasis*
Paralysis
Mucins