Tuberc Respir Dis.  2005 Jan;58(1):25-30. 10.4046/trd.2005.58.1.25.

Polymorphisms of Angiotensin-converting Enzyme Gene Associated in Patients with COPD with or without Bronchial Hyperresponsiveness

• Kim SS
• Choi EG
• Park SJ
• Lee HB
• Lee YC
• Rhee YK

• KMID: 2132196
• DOI: http://doi.org/10.4046/trd.2005.58.1.25

Abstract

BACKGROUND: An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and occurrence according to ACE gene insertion (I)/deletion (D) polymorphism. Also, the involvement of the ACE genes as the genetic basis of bronchial asthma is currently controversy. We investigated whether there was any association between polymorphisms of the ACE genes and airway hyper-responsiveness in chronic obstructive pulmonary disease (COPD).
METHODS
A total of 100 patients with COPD were enrolled in this study. The ACE genotypes were determined in all subjects by polymerase chain reaction. Pulmonary function test including bronchodilator response (BDR), methacholine bronchial provocation test (MBPT) were done in those patients. Airway hyper-responsiveness include any findings of positive BDR or MBPT.
RESULTS
In COPD patients, the ACE genotype distribution did not differ significantly among groups of patients with severities of COPD, and with or without airway hyper-responsiveness.
CONCLUSIONS
These results suggest that polymorphisms of the ACE gene may not be associated with airway hyper-responsiveness, development and severity of COPD.

Keyword

Angiotensins; Enzymes; Polymorphism; COPD

MeSH Terms

Angiotensins
Asthma
Bronchial Provocation Tests
Genotype
Humans
Methacholine Chloride
Mutagenesis, Insertional
Peptidyl-Dipeptidase A
Polymerase Chain Reaction
Pulmonary Disease, Chronic Obstructive*
Respiratory Function Tests
Angiotensins
Methacholine Chloride
Peptidyl-Dipeptidase A