Korean J Hepatobiliary Pancreat Surg.  2015 Nov;19(4):161-166. 10.14701/kjhbps.2015.19.4.161.

Comparison of survival outcomes after anatomical resection and non-anatomical resection in patients with hepatocellular carcinoma

Affiliations
  • 1Department of surgery, Chungnam National University Hospital, Daejeon, Korea. oxali@hanmail.net

Abstract

BACKGROUNDS/AIMS
Liver resection is a curative procedure performed worldwide for hepatocellular carcinoma (HCC). Deciding on the appropriate resection range for postoperative hepatic function preservation is an important surgical consideration. This study compares survival outcomes of HCC patients who underwent anatomical or non-anatomical resection, to determine which offers the best clinical survival benefit.
METHODS
One hundred and thirty-one patients underwent liver resection with HCC, between January 2007 and February 2015, and were divided into two groups: those who underwent anatomical liver resection (n=88) and those who underwent non-anatomical liver resection (n=43). Kaplan-Meier survival analysis and Cox regressions were used to compare the disease-free survival (DFS) and overall survival (OS) rates between the groups.
RESULTS
The mean follow-up periods were 27 and 40 months in the anatomical and non-anatomical groups, respectively (p=0.229). The 3- and 5-year DFS rates were 70% and 60% in the anatomical group and 62% and 48% in the non-anatomical group, respectively. The 3 and 5-year OS rates were 94% and 78% in the anatomical group, and 86% and 80% in the non-anatomical group, respectively. The anatomical group tended to show better outcomes, but the findings were not significant. However, a relative risk of OS between the anatomical and non-anatomical group was 0.234 (95% CI, 0.061-0.896; p=0.034), which is statistically significant.
CONCLUSIONS
Although statistical significance was not detected in survival curves, anatomical resection showed better results. In this respect, anatomical resection is more likely to perform in HCC patients with preserve liver function than non-anatomical resection.

Keyword

Hepatocellular carcinoma; Liver resection; Anatomical resection; Non-anatomical resection

MeSH Terms

Carcinoma, Hepatocellular*
Disease-Free Survival
Follow-Up Studies
Humans
Liver

Figure

  • Fig. 1 Disease-free and overall survival of the anatomical and non-anatomical groups by the Kaplan-Meier Method.

  • Fig. 2 Disease-free and overall survival of the anatomical and non-anatomical groups by the Cox regression model.

  • Fig. 3 Overall survival of the anatomical and non-anatomical group by the Cox regression model in patients with single tumor.


Reference

1. Lai EC, Fan ST, Lo CM, Chu KM, Liu CL, Wong J. Hepatic resection for hepatocellular carcinoma. An audit of 343 patients. Ann Surg. 1995; 221:291–298. PMID: 7717783.
Article
2. Kwak HW, Park JW, Nam BH, Yu A, Woo SM, Kim TH, et al. Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus-endemic area. J Gastroenterol Hepatol. 2014; 29:820–829. PMID: 24325272.
Article
3. Sangiovanni A, Prati GM, Fasani P, Ronchi G, Romeo R, Manini M, et al. The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients. Hepatology. 2006; 43:1303–1310. PMID: 16729298.
Article
4. Kanematsu T, Takenaka K, Matsumata T, Furuta T, Sugimachi K, Inokuchi K. Limited hepatic resection effective for selected cirrhotic patients with primary liver cancer. Ann Surg. 1984; 199:51–56. PMID: 6318677.
Article
5. Bismuth H, Houssin D, Ornowski J, Meriggi F. Liver resections in cirrhotic patients: a Western experience. World J Surg. 1986; 10:311–317. PMID: 3010585.
Article
6. Castells A, Bruix J, Bru C, Fuster J, Vilana R, Navasa M, et al. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology. 1993; 18:1121–1126. PMID: 8225217.
Article
7. Takano S, Oishi H, Kono S, Kawakami S, Nakamura M, Kubota N, et al. Retrospective analysis of type of hepatic resection for hepatocellular carcinoma. Br J Surg. 2000; 87:65–70. PMID: 10606913.
Article
8. Ercolani G, Grazi GL, Ravaioli M, Del Gaudio M, Gardini A, Cescon M, et al. Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence. Ann Surg. 2003; 237:536–543. PMID: 12677151.
9. Kondo K, Chijiiwa K, Makino I, Kai M, Maehara N, Ohuchida J, et al. Risk factors for early death after liver resection in patients with solitary hepatocellular carcinoma. J Hepatobiliary Pancreat Surg. 2005; 12:399–404. PMID: 16258809.
Article
10. Strasberg SM, Belghiti J, Clavien PA, Gadzijev E, Garden Jo, Lau WY, et al. The Brisbane 2000 terminology of liver anatomy and resections. Terminology Committee of the International Hepato-Pancreato-Biliary Association. HPB. 2000; 2:333–339.
11. Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC cancer staging manual. 7th ed. New York: Springer;2010. p. 175.
12. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7:462–503. PMID: 13160935.
13. Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, et al. Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg. 2005; 242:252–259. PMID: 16041216.
Article
14. Nagao T, Inoue S, Goto S, Mizuta T, Omori Y, Kawano N, et al. Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis. Ann Surg. 1987; 205:33–40. PMID: 3026259.
15. Fuster J, García-Valdecasas JC, Grande L, Tabet J, Bruix J, Anglada T, et al. Hepatocellular carcinoma and cirrhosis. Results of surgical treatment in a European series. Ann Surg. 1996; 223:297–302. PMID: 8604911.
16. Cucchetti A, Cescon M, Ercolani G, Bigonzi E, Torzilli G, Pinna AD. A comprehensive meta-regression analysis on outcome of anatomic resection versus nonanatomic resection for hepatocellular carcinoma. Ann Surg Oncol. 2012; 19:3697–3705. PMID: 22722807.
Article
17. Marubashi S, Gotoh K, Akita H, Takahashi H, Ito Y, Yano M, et al. Anatomical versus non-anatomical resection for hepatocellular carcinoma. Br J Surg. 2015; 102:776–784. PMID: 25847111.
Article
18. Tomimaru Y, Eguchi H, Marubashi S, Wada H, Kobayashi S, Tanemura M, et al. Equivalent outcomes after anatomical and non-anatomical resection of small hepatocellular carcinoma in patients with preserved liverfunction. Dig Dis Sci. 2012; 57:1942–1948. PMID: 22407377.
19. Regimbeau JM, Kianmanesh R, Farges O, Dondero F, Sauvanet A, Belghiti J. Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma. Surgery. 2002; 131:311–317. PMID: 11894036.
Article
20. Kosuge T, Makuuchi M, Takayama T, Yamamoto J, Shimada K, Yamasaki S. Long-term results after resection of hepatocellular carcinoma: experience of 480 cases. Hepatogastroenterology. 1993; 40:328–332. PMID: 8406301.
21. Tanaka K, Shimada H, Matsumoto C, Matsuo K, Nagano Y, Endo I, et al. Anatomic versus limited nonanatomic resection for solitary hepatocellular carcinoma. Surgery. 2008; 143:607–615. PMID: 18436008.
Article
22. Shirabe K, Shimada M, Kajiyama K, Gion T, Ikeda Y, Hasegawa H, et al. Clinicopathologic features of patients with hepatocellular carcinoma surviving >10 years after hepatic resection. Cancer. 1998; 83:2312–2316. PMID: 9840530.
23. Nagasue N, Yamanoi A, el-Assal ON, Ohmori H, Tachibana M, Kimoto T, et al. Major compared with limited hepatic resection for hepatocellular carcinoma without underlying cirrhosis: a retrospective analysis. Eur J Surg. 1999; 165:638–646. PMID: 10452257.
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