Korean J Hepatobiliary Pancreat Surg.  2015 Nov;19(4):173-180. 10.14701/kjhbps.2015.19.4.173.

Comparative analysis of intraoperative radiofrequency ablation versus non-anatomical hepatic resection for small hepatocellular carcinoma: short-term result

• Yune Y
• Kim S
• Song I
• Chun K

• KMID: 2130970
• DOI: http://doi.org/10.14701/kjhbps.2015.19.4.173

Abstract

BACKGROUNDS/AIMS
To compare the clinical outcomes of intraoperative radiofrequency ablation (RFA) and non-anatomical hepatic resection (NAHR) for small hepatocellular carcinoma (HCC).
METHODS
From February 2007 to January 2015, clinical outcomes of thirty four patients with HCC receiving RFA or NAHR were compared, retrospectively.
RESULTS
There was no difference of patient and tumor characteristic between the two groups that received RFA or NAHR. The 1, 2, and 3-year recurrence rates following RFA were 32.2%, 32.2% and 59.3% respectively, and 6.7%, 33.3% and 33.3% following NAHR respectively (p=0.287). The 1, 2 and 3-year overall survival (OS) rates following RFA were 100%, 88.9% and 76.2% respectively, and 100%, 85.6% and 85.6%, respectively, following NAHR (p=0.869). We did not find a definite statistical difference in recurrence rate and OS rate between the two groups. In the multivariate analysis, number of tumor was an independent prognostic factor for recurrence and albumin was an independent prognostic factor for OS.
CONCLUSIONS
We recommend non-anatomical hepatic resection rather than intraoperative RFA in small sized HCC, due to a higher recurrence rate in intraoperative RFA. Intraoperative RFA was inferior to non-anatomical hepatic resection in terms of recurrence rate. We need to select the optimal treatment considering liver function and possibility of recurrence.

Keyword

Hepatocellular carcinoma; Radiofrequency ablation; Liver resection

MeSH Terms

Carcinoma, Hepatocellular*
Catheter Ablation*
Humans
Liver
Multivariate Analysis
Recurrence
Retrospective Studies

Figure

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  Fig. 1 Patient selection process.

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  Fig. 2 Comparison of the recurrence rates after propensity matching analysis.

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  Fig. 3 Comparison of the overall survival rates after propensity matching analysis.

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