Ann Lab Med.  2014 Nov;34(6):463-465. 10.3343/alm.2014.34.6.463.

A Case of Salivary-Type Amylase-Producing Multiple Myeloma Presenting as Mediastinal Plasmacytoma and Myelomatous Pleural Effusion

• Ok SJ
• Kim IS
• Lee EY
• Kang JE
• Lee SM
• Song MK

• KMID: 2129572
• DOI: http://doi.org/10.3343/alm.2014.34.6.463

Abstract

No abstract available.

MeSH Terms

Aged
Amylases/blood/*metabolism/urine
Bone Marrow/pathology
Electrophoresis, Agar Gel
Gene Rearrangement
Humans
Immunohistochemistry
Isoenzymes/blood/metabolism/urine
Male
Multiple Myeloma/*diagnosis/metabolism/pathology
Plasmacytoma/pathology
Pleural Effusion, Malignant/pathology
Amylases
Isoenzymes

Figure

• 

  Fig. 1 Histologic examination of the pleural fluid (A), mediastinal mass (B and C), and bone marrow (D, E, and F). (A) Cytospin analysis of pleural fluid shows increased plasma cells with eccentric nuclei and abundant basophilic cytoplasm, consistent with myelomatous pleural effusion (Wright-Giemsa stain, ×200). (B) The histologic examination of mediastinal plasmacytoma reveals diffuse infiltration of mature plasma cells (hematoxylin and eosin stain, ×200). (C) Immunohistochemical staining of mediastinal plasmacytoma shows CD138 positivity (×1,000). (D) Bone marrow aspiration shows moderate proliferation of neoplastic plasma cells, consistent with plasma cell myeloma (Wright-Giemsa stain, ×1,000). (E and F) Immunohistochemical staining of bone marrow shows monoclonal proliferation of lambda-restricted plasma cells (kappa [E] and lambda [F] stains, ×200).

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  Fig. 2 Amylase isoenzyme electrophoreses of serum and urine shows that the level of the salivary-type isoenzyme is the highest, consistent with salivary-type amylase-producing myeloma.Abbreviations: S1, salivary-type isoenzyme 1; S2, salivary-type isoenzyme 2; S3, salivary-type isoenzyme 3; P1, pancreatic-type isoenzyme 1.

Reference

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