Ann Lab Med.  2014 Nov;34(6):463-465. 10.3343/alm.2014.34.6.463.

A Case of Salivary-Type Amylase-Producing Multiple Myeloma Presenting as Mediastinal Plasmacytoma and Myelomatous Pleural Effusion

Affiliations
  • 1Department of Laboratory Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 2Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea. iskim0710@gmail.com
  • 3Department of Laboratory Medicine, Jinhae Yonsei Hospital, Changwon, Korea.
  • 4Department of Hematology-Oncology, Busan Cancer Center, Pusan National University Hospital, Busan, Korea.

Abstract

No abstract available.


MeSH Terms

Aged
Amylases/blood/*metabolism/urine
Bone Marrow/pathology
Electrophoresis, Agar Gel
Gene Rearrangement
Humans
Immunohistochemistry
Isoenzymes/blood/metabolism/urine
Male
Multiple Myeloma/*diagnosis/metabolism/pathology
Plasmacytoma/pathology
Pleural Effusion, Malignant/pathology
Amylases
Isoenzymes

Figure

  • Fig. 1 Histologic examination of the pleural fluid (A), mediastinal mass (B and C), and bone marrow (D, E, and F). (A) Cytospin analysis of pleural fluid shows increased plasma cells with eccentric nuclei and abundant basophilic cytoplasm, consistent with myelomatous pleural effusion (Wright-Giemsa stain, ×200). (B) The histologic examination of mediastinal plasmacytoma reveals diffuse infiltration of mature plasma cells (hematoxylin and eosin stain, ×200). (C) Immunohistochemical staining of mediastinal plasmacytoma shows CD138 positivity (×1,000). (D) Bone marrow aspiration shows moderate proliferation of neoplastic plasma cells, consistent with plasma cell myeloma (Wright-Giemsa stain, ×1,000). (E and F) Immunohistochemical staining of bone marrow shows monoclonal proliferation of lambda-restricted plasma cells (kappa [E] and lambda [F] stains, ×200).

  • Fig. 2 Amylase isoenzyme electrophoreses of serum and urine shows that the level of the salivary-type isoenzyme is the highest, consistent with salivary-type amylase-producing myeloma.Abbreviations: S1, salivary-type isoenzyme 1; S2, salivary-type isoenzyme 2; S3, salivary-type isoenzyme 3; P1, pancreatic-type isoenzyme 1.


Reference

1. Masood A, Hudhud KH, Hegazi A, Syed G. Mediastinal plasmacytoma with multiple myeloma presenting as a diagnostic dilemma. Cases J. 2008; 1:116. PMID: 18717993.
Article
2. Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 2010; 21:325–330. PMID: 19633044.
Article
3. Delannoy A, Hamels J, Mecucci C, Fally P, Wallef G, de Fooz C, et al. Amylase-producing IgD-type multiple myeloma. J Intern Med. 1992; 232:457–460. PMID: 1280672.
Article
4. Ohtsuki T, Yawata Y, Wada H, Sugihara T, Mori M, Namba M. Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32). Br J Haematol. 1989; 73:199–204. PMID: 2479409.
Article
5. Lai JL, Zandecki M, Mary JY, Bernardi F, Izydorczyk V, Flactif M, et al. Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis. Blood. 1995; 85:2490–2497. PMID: 7537117.
Article
6. Sawyer JR, Tricot G, Mattox S, Jagannath S, Barlogie B. Jumping translocations of chromosome 1q in multiple myeloma: evidence for a mechanism involving decondensation of pericentromeric heterochromatin. Blood. 1998; 91:1732–1741. PMID: 9473240.
Article
7. Pinelli M, Bindi M, Rosada J, Scatena P, Castiglioni M. Amylase: a disease activity index in multiple myeloma. Leuk Lymphoma. 2006; 47:151–154. PMID: 16321841.
Article
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