1. Kasse CA, Hyppolito MA, Cruz OL, de Oliveira JA. Ototoxicity and otoprotection. Rev Bras Med. 2008; 4:105–115.
2. Aquino TJ, Oliveira JA, Rossato M. Ototoxicity and otoprotection in the inner ear of guinea pigs using gentamicin and amikacin: ultrastructural and functional aspects. Braz J Otorhinolaryngol. 2008; Nov-Dec. 74(6):843–852. PMID:
19582340.
3. Avent ML, Rogers BA, Cheng AC, Paterson DL. Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity. Intern Med J. 2011; 6. 41(6):441–449. PMID:
21309997.
Article
4. Begg EJ, Barclay ML. Aminoglycosides: 50 years on. Br J Clin Pharmacol. 1995; 6. 39(6):597–603. PMID:
7654476.
5. Murillo-Cuesta S, Contreras J, Cediel R, Varela-Nieto I. Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Lab Anim. 2010; 4. 44(2):124–131. PMID:
19858169.
Article
6. Kitasato I, Yokota M, Inouye S, Igarashi M. Comparative ototoxicity of ribostamycin, dactimicin, dibekacin, kanamycin, amikacin, tobramycin, gentamicin, sisomicin and netilmicin in the inner ear of guinea pigs. Chemotherapy. 1990; 36(2):155–168. PMID:
2311443.
Article
7. Rizzi MD, Hirose K. Aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg. 2007; 10. 15(5):352–357. PMID:
17823553.
Article
8. Jiang H, Sha SH, Schacht J. NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. J Neurosci Res. 2005; 3. 79(5):644–651. PMID:
15672440.
9. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008; 8. 22(4):447–452. PMID:
18705755.
10. Ashraf SS, Rao MV, Kaneez FS, Qadri S, Al-Marzouqi AH, Chandranath IS, et al. Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress. J Chromatogr Sci. 2011; 4. 49(4):321–326. PMID:
21439125.
Article
11. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol. 2003; 5. 26(2):87–98. PMID:
12816394.
Article
12. Morsi NM. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol. 2000; 49(1):63–74. PMID:
10997492.
13. Al-Amri AM, Bamosa AO. Phase I safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease. Shiraz E Med J. 2009; 7. 10(3):107–111.
14. Institute of Laboratory Animal Research, Commission on Life Sciences, National Research Council. The guide for the care and use of laboratory animals. 7th ed. Washington DC: National Academies Press;1996.
15. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004; 4. 37(4):277–285. PMID:
15003729.
Article
16. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 12. 38(12):1103–1111. PMID:
16214125.
Article
17. Forge A, Schacht J. Aminoglycoside antibiotics. Audiol Neurootol. 2000; Jan-Feb. 5(1):3–22. PMID:
10686428.
Article
18. Miman MC, Ozturan O, Iraz M, Erdem T, Olmez E. Amikacin ototoxicity enhanced by Ginkgo biloba extract (EGb 761). Hear Res. 2002; 7. 169(1-2):121–129. PMID:
12121745.
Article
19. Lenoir M, Puel JL. Dose-dependent changes in the rat cochlea following aminoglycoside intoxication. II. Histological study. Hear Res. 1987; 26(2):199–209. PMID:
3570998.
20. Xuan W, Dong M, Dong M. Effects of compound injection of Pyrola rotundifolia L and Astragalus membranaceus Bge on experimental guinea pigs' gentamicin ototoxicity. Ann Otol Rhinol Laryngol. 1995; 5. 104(5):374–380. PMID:
7747908.
Article
21. Dulon D, Hiel H, Aurousseau C, Erre JP, Aran JM. Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence. C R Acad Sci III. 1993; 7. 316(7):682–687. PMID:
8019890.
22. Guthrie OW. Aminoglycoside induced ototoxicity. Toxicology. 2008; 7. 249(2-3):91–96. PMID:
18514377.
Article
23. Selimoglu E. Aminoglycoside-induced ototoxicity. Curr Pharm Des. 2007; 13(1):119–126. PMID:
17266591.
Article
24. Fausti SA, Henry JA, Schaffer HI, Olson DJ, Frey RH, McDonald WJ. High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. J Infect Dis. 1992; 6. 165(6):1026–1032. PMID:
1583319.
Article
25. Stavroulaki P, Vossinakis IC, Dinopoulou D, Doudounakis S, Adamopoulos G, Apostolopoulos N. Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2002; 2. 128(2):150–155. PMID:
11843723.
Article
26. Tran Ba Huy P, Bernard P, Schacht J. Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. J Clin Invest. 1986; 5. 77(5):1492–1500. PMID:
3700652.
Article
27. Sassada MM, Ceccon ME, Navarro JM, Vaz FA. Hearing loss in newborn admitted in intensive care unit. Pediatria (Sao Paul). 2005; 27:163–171.
28. Conlon BJ, Aran JM, Erre JP, Smith DW. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear Res. 1999; 2. 128(1-2):40–44. PMID:
10082281.
29. Nekrassov V, Sitges M. Vinpocetine protects from aminoglycoside antibiotic-induced hearing loss in guinea pig in vivo. Brain Res. 2000; 6. 868(2):222–229. PMID:
10854574.
Article
30. Oliveira JA, Canedo DM, Rossato M, Andrade MH. Self-protection against aminoglycoside ototoxicity in guinea pigs. Otolaryngol Head Neck Surg. 2004; 9. 131(3):271–279. PMID:
15365547.
Article
31. Erdem T, Ozturan O, Iraz M, Miman MC, Olmez E. Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats. Eur Arch Otorhinolaryngol. 2005; 4. 262(4):314–321. PMID:
15170574.
Article
32. Lecain E, Omri B, Behar-Cohen F, Tran Ba, Crisanti P. The role of PKCzeta in amikacin-induced apoptosis in the cochlea: prevention by aspirin. Apoptosis. 2007; 2. 12(2):333–342. PMID:
17191118.
33. Berkiten G, Salturk Z, Topaloglu I, Ugrad H. Protective effect of pentoxifylline on amikacin-induced ototoxicity in rats. Am J Otolaryngol. 2012; Nov-Dec. 33(6):689–692. PMID:
22784588.
Article
34. Amora Lde A, Murashima Ade A, Rossato M, Moreira MB, Hyppolito MA, Fagundes DJ. The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs. Braz J Otorhinolaryngol. 2013; May-Jun. 79(3):342–348. PMID:
23743750.
35. Bayindir T, Filiz A, Iraz M, Kaya S, Tan M, Kalcioglu MT. Evaluation of the protective effect of Beta glucan on amikacin ototoxicity using distortion product otoacoustic emission measurements in rats. Clin Exp Otorhinolaryngol. 2013; 3. 6(1):1–6. PMID:
23525870.
Article
36. Pavlidis P, Maurer J, Apostolidou E, Kekes G, Kouvelas D. Memantine's action against aminoglycoside-induced ototoxicity. Eur Arch Otorhinolaryngol. 2014; 6. 271(6):1491–1496. PMID:
23917735.
Article
37. Duan M, Agerman K, Ernfors P, Canlon B. Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity. Proc Natl Acad Sci U S A. 2000; 6. 97(13):7597–7602. PMID:
10861021.
Article
38. Sagit M, Korkmaz F, Akcadag A, Somdas MA. Protective effect of thymoquinone against cisplatin-induced ototoxicity. Eur Arch Otorhinolaryngol. 2013; 8. 270(8):2231–2237. PMID:
23161274.
Article
39. Jaswal A, Sinha N, Bhadauria M, Shrivastava S, Shukla S. Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage. Environ Toxicol Pharmacol. 2013; 11. 36(3):779–786. PMID:
23958970.
Article
40. Strupp M, Arbusow V. Acute vestibulopathy. Curr Opin Neurol. 2001; 2. 14(1):11–20. PMID:
11176212.
41. Klemens JJ, Meech RP, Hughes LF, Somani S, Campbell KC. Antioxidant enzyme levels inversely covary with hearing loss after amikacin treatment. J Am Acad Audiol. 2003; 4. 14(3):134–143. PMID:
12859138.
Article
42. Sankaranarayanan C, Pari L. Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats. Chem Biol Interact. 2011; 4. 190(2-3):148–154. PMID:
21382363.
Article
43. Nagi MN, Al-Shabanah OA, Hafez MM, Sayed-Ahmed MM. Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J Biochem Mol Toxicol. 2011; May-Jun. 25(3):135–142. PMID:
20957680.
Article
44. World Health Organization, Programme for the Prevention of Deafness and Hearing Impairment (PDH). Report of an informal consultation on strategies for prevention of hearing impairment from ototoxic drugs. Geneva: World Health Organization;1994.
45. Infectious Diseases Society of America. The 10 × '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin Infect Dis. 2010; 4. 50(8):1081–1083. PMID:
20214473.
46. Norrby SR, Nord CE, Finch R. European Society of Clinical Microbiology and Infectious Diseases. Lack of development of new antimicrobial drugs: a potential serious threat to public health. Lancet Infect Dis. 2005; 2. 5(2):115–119. PMID:
15680781.
Article
47. Vanamala J, Kester AC, Heuberger AL, Reddivari L. Mitigation of obesity-promoted diseases by Nigella sativa and thymoquinone. Plant Foods Hum Nutr. 2012; 6. 67(2):111–119. PMID:
22477645.
Article