J Korean Ophthalmol Soc.  2008 Feb;49(2):230-237. 10.3341/jkos.2008.49.2.230.

Two-year Endothalial Changes after Iris Fixed Phakic Intraocular Lens Implantation in Korean

• Choi WS
• Choi BJ
• Her J

• KMID: 2127113
• DOI: http://doi.org/10.3341/jkos.2008.49.2.230

Abstract

PURPOSE: To investigate quantitative and morphometric endothelial changes in phakic eyes implanted with an iris-fixed phakic intraocular lens in Korean patients.
METHODS
We prospectively examined the endothelial cell density (ECD), ECD loss (ECL), coefficient variations (CV), and frequency of Hexagons (6A) in 46 phakic eyes implanted with an iris-fixed phakic intraocular lens. The effect of anterior chamber depth (ACD) and diopter of iris-fixed phakic intraocular lens on ECD was statistically analyzed.
RESULTS
Preoperative mean ECD was 2923+/-257 cells/mm2. ECL at postoperative 1, 3, 6, 12, and 24 monthswas 0.71%, 0.88%, 0.70%, 0.64%, and 2.34%. It was significant only in the month 24 results. The mean CV value at the same time was 0.343, 0.342, 0.334, 0.329, 0.326, and 0.338. The change was significant at the 12th month. The mean 6A value at the same time was 58.2%, 57.8%, 59.7%, 59.6%, 60.1%, and 58.8%. There was no significant change in 6A value. Preoperative ACD and diopter of iris-fixed phakic intraocular lens didn't affect the ECD change.
CONCLUSIONS
This two-year follow-up study of changes in endothelial cells after implantation iris-fixated phakic intraocular lens showed statistically significant decreases in the cells, which is not very significant considering the physiologic reduction rate of the cells. Thses decreases showed a tendency to be stabilized with recovery of morphological changes. Further long-term follow-up is needed to determine its long-lasting effect.

Keyword

Endothelial cell density; Iris fixed phakic intraocular lens; Morphometric change

MeSH Terms

Anterior Chamber
Endothelial Cells
Eye
Follow-Up Studies
Humans
Iris
Phakic Intraocular Lenses
Prospective Studies

Figure

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  Figure 1. Diagram of the 6-mm Artisan lens (Ophtec BV, Groningen, Netherlands) with relevant dimensions. The haptics lie in the pupillary planes, whereas the optic vaults anterior to the pupil to prevent iris chafing.

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  Figure 2. Critical distance (S). At least, more than 1 mmis recommended for preventing iris rubbing or IOL movement.

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  Figure 3. Center method in calculating endothelial cell density. After 100 cell dotting, endothelial cell density is calculated automatically.

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  Figure 4. Endothelial cell density changes at two-year follow-up.

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  Figure 5. Morphologic changes in coefficient variation (CV) and frequency (6A) of hexagons (%) at two-year follow-up.

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  Figure 6. Scatter plot showing the relationship between anterior chamber depth (ACD) and endothelial cell density chage (ECD change) after 24months and between diopter of intraocular lens (IOL) and endothelial cell density change (ECD change) after 24 months.

Reference

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