J Korean Ophthalmol Soc.
2002 Feb;43(2):419-423.
Corneal Ulcer and Chronic Conjunctivitis Due to Ofloxacin-resistant MRSA
- Affiliations
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- 1Department of Ophthalmology, Kangnam St. Marys' Hospital, Catholic University Medical College, Korea.
- 2Apkujong St. Mary's Eye Center, Korea. twhahn@hotmail.com
Abstract
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PURPOSE: Considering popular use of fluoroquinolone eyedrops in Korea, it is important to know emerging resistant strain in treating infectious eye disease. We report methicillin resistant Staphylococcus aureus after frequent use of ofloxacin eyedrop in corneal ulcer and chronic conjunctivitis.
METHODS
Four strains of ofloxacin-resistant MRSA (Methicillin-Resistant Staphylococcus Aureus) in patients with keratitis and conjunctivitis were found in our study. One strain was detected in a patient who used ofloxacin eyedrops intermittently for the treatment of recurrent corneal erosion which resulted from a bullous keratopathy after graft failure, and the others were detected in three patients using ofloxacin eyedrops intermittently or continuously for the treatment of conjunctivitis over 1 year.
RESULTS
As fluoroquinolone eyedrop has been used more frequently, it is presumed that antibiotic resistance rate of ocular strains to ofloxacin might be increased. Therefore, a careful use of topical antibiotics based on the culture and antibiotic sensitivity test should be emphasized for the successful treatment of infectious ocular diseases.
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