J Korean Ophthalmol Soc.
1997 Feb;38(2):207-213.
The Antibacterial Activity of Domestic Toipcal Antibiotics II: In Vitro
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul Korea.
Abstract
- To Assess the efficacy of the new domestic topical antibiotic eyedrops, we evaluated in vitro the antimicrobial activity of Ciprus (ciprofloxacin), Ofloxacin (ofloxacin), Tobramycin (tobramycin), and Ecolicin (erythromycin and colistin) ophthalmic solutions against the experimental strains of methicillin resistant S. aureus(MRSA), methicillin sensitive S. aureus(MSSA), S. epidermidis, P. aeruginosa, and E. aerogenes. We performed this study with antibiotics disc diffusion method for standard bacterial sensitivity and the modification of Reddish method in ophthalmic solutions. Ciprus, Ofloxacin, and Tobramycin inhibited all of the experimental bacterial strains, including the resistant strain under antibiotic disc diffusion method, within 1 hour exposure time. Ecolicin did not inhibit MRSA nutil 16-24 hour exposure time, but inhibited all other experimental strains within 2 hour exposure time, In spite of bacterial resistance under antibiotics disc diffusion method, the majority of topical antibiotics tested in our study had inhibitory activity against the experimental strains.
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