J Korean Ophthalmol Soc.  1996 Oct;37(10):1601-1606.

Efficacy of Ciprofloxacin-soaked Collagen Shields for Treatment of Experimental Staphylococcus aureus Keratitis in Rabbits

• Lee YH
• Hahn YH
• Kim KH

Abstract

In order to study the efficacy of a 0.2% ciprofloxacin-soaked collagen shield for the treatment of Staphylococcus aureus keratitis, an experimental study was performed on 40 eyes of 20 rabbits. Twenty hours after intrastromal injection with S. aureus, the rabbits were divided into four groups: Group 1(10 eyes) was treated with a 0.2% ciprofloxacin-soaked collagen shield with an additional instillation of 0.2% ciprofloxacin drops every 30 minutes for 4 hours; Group 2 (10 eyes) was treated with a 0.2% ciprofloxacin-soaked collagen shield for 4 hours; Group 3 (10 eyes) was treated with 0.2% ciprofloxacin drops every 30 minutes for 4 hours; Group 4 (10 eyes) received BSS every 30 minutes for 4 hours as a control. Bacterial killing was quantitated by culturing corneal homogenates and calculating the number of viable bacteria (colony-forming units) per cornea. Groups 1, 2, and 3 showed significantly reduced numbers of bacteria compared with the control (p<0.01). The order of efficacy in the treatment for S. aureus keratritis were groups 1, 2 and 3, respectively, but the statistical difference was not significant among groups 1, 2, and 3(p>0.05). These results suggested that a 0.2% ciprofloxacin-soaked collagen shield may be an effective and convenient mode of therapy for S. aureus keratitis.

Keyword

0.2% ciprofloxacin; collagen shield; Staphylococcus aureus keratitis

MeSH Terms

Bacteria
Ciprofloxacin
Collagen*
Cornea
Homicide
Keratitis*
Rabbits*
Staphylococcus aureus*
Staphylococcus*
Ciprofloxacin
Collagen