J Korean Ophthalmol Soc.  1993 May;34(5):474-479.

A Case of VADS Induced by Immunosuppessants Therapy in Uveitis Patient

• Shin SG
• Chung EH
• Yoon IH
• Won IG

Abstract

VAHS is characterized by viral-like prodromal symptoms, high fever' malaise, hepatosp lenomegaly, pancytopenia. The dignosis is based on a bone marrow biopsy specimen that demonstrates histiocytic hyperplasia with prominent hemophagocytosis of red blood cells, platelets, and nucleated hematopoietic cells Recently, the use of immunosuppressants tends to increase due to increase of autoimmune disease and organ transplantation patients. A large portion of leukemia and organ transplant patients developed VAHS as a secondary viral infection after anticancer drug and immunosuppressants therapy was administered In the field of ophthalmology, VAHS can occur by administration of immunosuppressants in corneal transplantation and autoimmune uveitis patients. Recently we experienced a case of fatal VAHS in a young uveitis patient who had been treated with immunosuppressants. We report this specfic case with literature review bec,lUse of the need for careful observation of general findings occurring during treatment of immunosuppressants such as corticosteroid.

Keyword

Immunosuppressants; Uveitis; VAHS

MeSH Terms

Autoimmune Diseases
Biopsy
Bone Marrow
Corneal Transplantation
Erythrocytes
Humans
Hyperplasia
Immunosuppressive Agents
Leukemia
Ophthalmology
Organ Transplantation
Pancytopenia
Prodromal Symptoms
Transplants
Uveitis*
Immunosuppressive Agents