J Korean Ophthalmol Soc.
1989 Feb;30(1):29-36.
Topical Autologous Fibronectin in the Treatment of Persistent Corneal Epithelial defects
- Affiliations
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- 1Department of Ophthalmology, Keimyung University, School of Medicine, Korea.
- 2Department of Biochemistry, Kyungpook University, School of Medicine, Daegu, Korea.
Abstract
- Fibronectin, a glycoprotein, is present in plasma and extracellular matrix and is responsible for cellular adhesion. Fibronectin was purified from autologous plasma of two persistent corneal epithelial defect patients by affinity chromatogaphy and administered topically 500 micro ml, 2 dropsper time, five times a day for 3 weeks. Reepithelization began three to seven days after initiation of treatment with autologous purified fibronectin eyedrops, and epithelial defects healed nearly completely and subjective symptoms were relieved. No side effects were observed. Over a follow-up period of 4 to 23 wks, no recurrences were noted.
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