J Korean Ophthalmol Soc.  1986 Oct;27(5):769-780.

The Retinal Changes in an Experimental Vitreous Hemorrhage

• Lee KY
• Hahn DK

Abstract

The effect of vitreous hemorrhage on the retinal structures was studied in twenty young adult pigmented rabbits weighing 2 to 3kgs. The autologous blood was injected intra-vitreally in one eye of the animals. Five animals of each group were sacrificed for light and electron microscopic studies of the retina near the visual streak in the posterior pole in one week, two weeks, one month and two months. In light microscopy of the rabbit retina, hemosiderin-laden macrophages are located in the vitreous cavity. Iron stain positive particles are present in the retina, particularly in the pigment epithelium. These particles are also scattered in the retina after two weeks on. By electron microscopy, there is no significant ultrastructural change in one week. Swelling of mitochondria in the bipolar and Miiller cells, and in the inner segments of the cone cells are noted along with disarrangement of disc stacking in 2 weeks. Many myelin figures appear in the cytoplasm of the inner segments of visual sells, outer plexiform and inner nuclear layers. Hemosiderin pigments appear in the pigment cells and in the cytoplasm Muller cells. In inner nuclear layer, a necrotizing cell demonstrates pyknotic nucleus and focal cytoplasmic degradation in one month. Hemosiderin pigments are present in ganglion cells, Miiller cells and pigment epithelial cells. Disc stacking is altered in outer segment of the visual cells, and the pigment epithelial cell demonstrate increased engulfment of outer segment of visual cells in two months. However, the electrophysiological study with ERG do not demonstrate any abnormality.

MeSH Terms

Animals
Cytoplasm
Ependymoglial Cells
Epithelial Cells
Epithelium
Ganglion Cysts
Hemosiderin
Humans
Iron
Macrophages
Microscopy
Microscopy, Electron
Mitochondria
Myelin Sheath
Rabbits
Retina
Retinaldehyde*
Vitreous Hemorrhage*
Young Adult
Hemosiderin
Iron
Retinaldehyde