J Korean Ophthalmol Soc.
1975 Dec;16(4):319-324.
Effects of Hydrophilic Contact Lens on the Rabbit Corneal Ulcer
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- The beneficial effects of a hydrophilic contact lens of the corneal lesions, such as bandage or splint effect and prolonged delivery of drugs from a soaked hydrophilic contact lens were well informed by the previous reports. The authors investigated the effectiveness of the soft contact lens soaked with antibiotics for the treatment of experimentally induced bacterial corneal ulcer of the rabbits. In group 1, corneal defects of both eyes were made with a trephine of 5mm in diameter and 0.2mm in depth in 6 rabbits. A sterilized soft contact lens was inserted into one eye of each animal and lens was changed everyday. The other eye was not treated. The mean duration for the epithelial coverage of the defects were 7.4 days in the lens inserted eyes and 7.2 days in the untreated eyes. There were no significant statistical differences in the healing rate between the lens imerted eyes and control ones. In group 2, seven rabbits were inoculated with staphylococcus aureus suspension, which was susceptible to chloramphenicol (CM). Corneal ulcers developed 24 hours later. The soft contact lens soaked with 1% CM solution was placed in one eye of each animal for 24 hours and changed everyday. The other eye was treated with 1% CM solution dropping 4 times daily. The ulcer began to heal about 6 days later. Evaluation of the heaJing was performed by measurement of the size of ulcer for the first 12 days and grading of the healed cornea by modified Wiggins grading system at the end of the experiment. In grout 3, corneal ulcer developed in 7 rabbits 48 hours later after inoculation of pseudomonas aeruginosa. One eye of each animal was treated with soft contact lens soaked with 1% gentamicin solution and the lens was changed everyday. The other eye was treated with 1% gentamicin solution dropping 4 times daily. The mean duration of healing of the corneal ulcer in group 2 was 15.2 days in the lens inserted eyes and 13.7 days in the control ones. By the modified Wiggins grade the outcome of the infection revealed better results in the eyes treated with 1% CM solution dropping. In group 3, the mean duration of healing of the corneal ulcer was 16.2 days in the lens ineerted eyes and 15.7 days in the control eyes. The modified Wiggins grade showed no significant statistical differences between the lens inserted eyes and control ones.
