J Korean Soc Plast Reconstr Surg.  2006 May;33(3):330-334.

Bacteriology and Antibiotic Sensitivity for Diabetic Foot Ulcer

• Choi SR
• Lee CK
• Kim DW
• Han SK
• Kim WK

Abstract

Polymicrobial nature of diabetic foot infection has been well documented in the literature. Initial antibiotic therapy of diabetic foot infection is usually empiric until reliable culture data is shown. This study was carried out to determine the common bacteriological flora of diabetic foot infection and antimicrobial sensitivity pattern in order to enhance possible empiric treatment. The specimens were obtained from wounds of 207 cases of diabetic foot ulcer, and the bacteriological isolation, and antimicrobial susceptibility tests of the isolates were carried out by standard microbiological methods. Staphylococcus aureus was the most common isolate, with 46.2% of recover rate among total bacterial isolated cases. Among gram-negative organisms, Pseudomonas aeruginosa was most common. Gram-positive organisms showed significant susceptibility to clindamycin, trimethoprim/sulfamethoxazole, and levofloxacin, besides vancomycin. Cefoperazone, piperacillin/tazobactam, and amikacin in addition to imipenem were most effective agents compared to gram-negative organisms. Diabetic foot infection requires use of combined antimicrobial therapy for initial management. Our results indicate that the most effective antibiotic combination for diabetic foot infection of Korean patients is clindamycin plus cefoperazone.

Keyword

Diabetic foot; Microbiology; Antibiotic therapy

MeSH Terms

Amikacin
Bacteriology*
Cefoperazone
Clindamycin
Diabetic Foot*
Humans
Imipenem
Levofloxacin
Pseudomonas aeruginosa
Staphylococcus aureus
Ulcer*
Vancomycin
Wounds and Injuries
Amikacin
Cefoperazone
Clindamycin
Imipenem
Vancomycin