J Korean Assoc Oral Maxillofac Surg.
2004 Feb;30(1):17-24.
Biologigic membrane for guided bone regeneration
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University.
- 2Department of Dentistry, Samsung Medical Center.
Abstract
- The purpose of this study was to evaluate the stability and efficacy of biologic membrane made of freeze-dried cartilage as a barrier to facilitate guided bone regeneration in experimental non-healing bone defects in the rat mandible. Nine adult Sprague-Dawley rats (400-500g) were used in experiment. 5.0mm in diameter were created on the mandibular angle area by means of slow-speed trephine drill. In microscopic examination, dynamic immature bone forming at 2 weeks and its calcification at 4 weeks were observed. The membrane made of lyophilized cartilage taken from human costal cartilage seems to be very effective for guided bone regeneration as a biologic membrane and the scaffold for attachment of cells or local drug delivery system of growth factor, which may meet the ideal requirement of a barrier membrane and graft materials.
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