J Korean Radiol Soc.  1995 Apr;32(4):557-562.

Gray Matter Heterotopias: MR and Clinical Features

Abstract

PURPOSE
To evaluate types of gray matter heterotopias, associated brain anomalies, and its correlation with the patterns of seizure.
MATERIALS AND METHODS
We evaluated retrospectively 19 patients(male :female=10:9, mean age 21 years) with gray matter heterotopias on brain MRI. Using 1.0T superconducting MR unit, spin echo TI-, proton-density- and T2-weighted images in axial, coronal and sagittal planes were obtained.
RESULTS
Types of gray matter heterotopias were single subependymal in four patients, multiple subependymal in one, focal subcortical in eight, diffuse subcortical in two, mixed multiple subependymal and focal subcortical in four. Associated anomalies were seen in 11 patients:other neuronal migration anomalies in eight patients, corpus callosum agenesis in two, and combined holoprosencephaly and Dandy-Walker malformation in one. Fifteen patients had seizure. The patterns of seizure were not correlated with the types of heterotopias.
CONCLUSION
In addition to subependymal, focal subcortical, and diffuse subcortical types, gray matter heterotopias included mixed variant of of multiple subependymal and subcortical type. Schizencephaly was the most common form of accompanying anomalies, and patterns of seizure were not correlated with types of gray matter heterotopias, even though main clinical menifestation was seizure.


MeSH Terms

Agenesis of Corpus Callosum
Brain
Dandy-Walker Syndrome
Holoprosencephaly
Humans
Magnetic Resonance Imaging
Malformations of Cortical Development
Neurons
Retrospective Studies
Seizures
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