Korean J Dermatol.  1995 Feb;33(1):172-178.

A Case of Primary Disseminated Cutaneous Aspergillosis in Chrinic Active hepatitis

• Kwon HJ
• Jung JB
• Lee KS
• Song JY

Abstract

An 41-year-old woman with chronic active hepatitis developed multible asymptomatic erythematous papules, plaques and purpuras on the both lower leg, feet, forearms and hands. Some lesions progressed to ulcers with central black colored necrotic eschars. Biopsies and cultures demorrstrated a fungus, aspergillus fumigatus a the etilogic agent. No evicience of involvement of other organs by aspergillus fumigatus was found. Intravenous amphotericin B therapy was discontinued because of he immediate adverse effects. The patient received treatment with oral itaconazole(200mg/day) and intravenous fluconazole(400mg/day), but skin lesions have been recurring repeatedly.

Keyword

Aspergillosis; ltraconazole; Fluconazole

MeSH Terms

Adult
Amphotericin B
Aspergillosis*
Aspergillus fumigatus
Biopsy
Female
Fluconazole
Foot
Forearm
Fungi
Hand
Hepatitis*
Hepatitis, Chronic
Humans
Leg
Purpura
Skin
Ulcer
Amphotericin B
Fluconazole