Korean J Infect Dis.
2002 Jun;34(3):184-190.
Comparative Study on the Incidence of Urinary Tract Infection between Nitrofurazone-Coated Urinary Catheter and Silicone Catheter
- Affiliations
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- 1Department of Urology, College of Medicine, The Catholic University of Korea, Korea.
- 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Korea.
- 3Department of Urology, College of Medicine, Seoul National University, Korea.
- 4Department of Urology, College of Medicine, University of Ulsan, Korea.
- 5Department of Urology, College of Medicine, Yonsei University, Seoul, Korea.
Abstract
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PURPOSE: To evaluate the efficacy and safety of nitofurazone-coated urinary catheter in inhibitory activity of catheter associated urinary tract infection (CAUTI).
METHODS
From March to September 2001, 177 patients in five university hospitals who were expected to use urinary catheters and be satisfied with the inclusion, exclusion criteria were analyzed. Through urine culture, we compared the incidence rate and onset of CAUTI after catheterization of standard silicone urinary catheters (control group) and nitofurazone-coated catheters (experimental group). CAUTI was defined as over 103 CFU/mL of bacteria in urine culture. The catheter surface was examined by scanning electron microscopy (SEM) to analyze the bacteial biofilms.
RESULTS
The incidence rate of CAUTI was lower in experimental group than in control group but there was no statistical significancy. However, in the patients who had indwelling urinary catheters for 5~7 days, the incidence rate of CAUTI was significantly low in experimental group. Depending on catheter insertion period, the incidence onset of CAUTI was analyzed. It was found that the longer the insertion period was, the lower the incidence rate of CAUTI in experimental group was than in control group, but there was no statistical significancy. In the patients who had indwelling urinary catheters for 5~7 days, the incidence rate of CAUTI was significantly low in experimental group. According to the result of this study, patient who was older and had longer insertion- period, had higher incidence rate of CAUTI. SEM showed the formation of bacterial biofilm in silicone catheters throughout the 5~7 days, but deterioration of the bacterial biofilm was visible on the surface of nitofurazone-coated catheters. There was no side-effect in any groups.
CONCLUSION
This study suggests that nitofurazone-coated catheters can be useful for inhibition of urinary tract infection, with systemic and local safety, in patients who have indwelling urinary catheter more than 5 days and old-age paitents.
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