J Korean Ophthalmol Soc.  2006 Sep;47(9):1401-1409.

A Correlation with Retinal Thickness Using Retinal Thickness Analyzer and the Responses of Multifocal Electroretinogram in Patients with Diabetic Macular Edema

• Sung MS
• Park TK
• Lee JH
• Ohn YH

Abstract

PURPOSE: To assess the correlation between retinal thickness determined with a retinal thickness analyzer (RTA) and the responses of multifocal electroretinogram (mfERG) in patients with diabetic macular edema.
METHODS
RTA and mfERG were performed in patients with diabetic macular edema (20eyes, 10 patients) and normal subjects (10eyes, 10 patients). The measured retina of RTA and mfERG overlapped based on the anatomical landmarks of the fundus. The center of macula was defined as "Area 1", and the central 5 degree retina including the center of macula was defined as "Area 2". The correlations between retinal thickness and the local responses in each area were assessed.
RESULTS
The mean retinal thickness of patients with diabetic macular edema was significantly greater than that of normal subject, and the results of mfERG typically represented decreased amplitudes and delayed latencies. In the matching of retinal thickness and local responses in Area 2, amplitudes of N1 & P1 decreased and latency of P1 delayed as the retinal thickness increased. The correlation was prominent in patients with diabetic macular edema.
CONCLUSIONS
In the matching of RTA and mfERG of patients with diabetic macular edema, retinal thickness and local responses were significantly correlated.

Keyword

Diabetic macular edema; Local responses; Multifocal ERG; Retinal thickness; RTA

MeSH Terms

Humans
Macular Edema*
Retina
Retinaldehyde*
Retinaldehyde