J Korean Ophthalmol Soc.  2010 Jan;51(1):29-34.

Correlation Between Multifocal Electroretinography and Visual Acuity After Resolution of Diabetic Macular Edema

• Lee KH
• Chang MH
• Ahn JH

Abstract

PURPOSE
To evaluate the prognostic value of multifocal electroretinography (mfERG) after a decrease of retinal thickness in eyes with diabetic macular edema (DME).
METHODS
Sixty patients (60 eyes) underwent intravitreal injection of triamcinolone acetonide or bevacizumab for diabetic macular edema. Eyes were divided into three groups, according to foveal thickness : Group A (<500 micrometer, n=20 eyes), Group B (500 micrometer <== <800 micrometer, n=20 eyes), and Group C (>==800 micrometer, n=20 eyes). Best-corrected visual acuity (BCVA) and mfERG responses from the most central seven hexagons were analyzed both before and after treatment.
RESULTS
The pre-injection P1 amplitudes of mfERG correlated significantly with end-point BCVA in Groups A and B (p<0.05), but did not correlate with end-point BCVA (p>0.05) in Group C.
CONCLUSIONS
The level of P1 amplitudes of mfERG may be a useful tool to predict visual outcomes after a decrease of retinal thickness in patients with diabetic macular edema.

Keyword

Diabetic macular edema; Multifocal electroretinography; Visual acuity

MeSH Terms

Antibodies, Monoclonal, Humanized
Electroretinography
Eye
Humans
Intravitreal Injections
Macular Edema
Retinaldehyde
Triamcinolone Acetonide
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde
Triamcinolone Acetonide

Figure

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  Figure 1. Stimulus array of 61 hexagonal elements; ring 1 (red) and ring 2 (blue) correspond to the fovea and parafovea, respectively.

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  Figure 2. The typical waveform of the primary multifocal ERG response is a biphasic wave with initial negative deflection followed by a positive peak. There may be a second negative deflection after the peak. The preferred designation is to label these three peaks respectively N1, P1, and N2.

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  Figure 3. Scattergram demonstrating the relation between preinjection P1 amplitudes and end point BCVA in three groups. Group A (r=-0.772, p<0.001) and B (r=-0.651, p=0.001) show that preinjection P1 amplitude significantly related to the end point BCVA, but in group C, no significant relation between preinjection P1 amplitude and end point BCVA.

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  Figure 4. Comparison of P1 amplitudes of Group A, B and C between preinjection and end point state. The box- and -whiskers plots include the 25 th, 50 th, and 75 th percentiles. The whiskers define the minimum and maximum values.

Reference

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