J Korean Ophthalmol Soc.  2015 Sep;56(9):1345-1352. 10.3341/jkos.2015.56.9.1345.

Correlation between Macular GCIPL Thickness and Visual Acuity after Resolution of Diabetic Macular Edema

• Park JM
• Lee YC
• Kim ST

• KMID: 2214548
• DOI: http://doi.org/10.3341/jkos.2015.56.9.1345

Abstract

PURPOSE
To evaluate the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in eyes with resolved diabetic macular edema (DME).
METHODS
Twenty eyes of diabetic retinopathy patients with resolved DME (DME group) after treatment, and 20 eyes of diabetic retinopathy patients without DME (no-DME group) were included in this study. The pRNFL thickness, mGCIPL thickness and central macular thickness (CMT) were measured using spectral-domain optical coherence tomography (SD-OCT). Analyses were performed to determine the correlation between the different thicknesses and the visual function.
RESULTS
No significant difference in mean CMT was observed between the DME and no-DME groups. Average pRNFL thickness in the DME group was thicker than in the no-DME group (p = 0.003). Average mGCIPL thickness in the DME group was thinner than in the no-DME group (p = 0.030). Final visual acuity was significantly correlated with average mGCIPL thickness and minimum mGCIPL thickness, but not pRNFL thickness and CMT in the DME group.
CONCLUSIONS
mGCIPL thickness decreased in the DME group compared with the no-DME group and was correlated with the visual acuity. These results suggested that inner retinal injury in patients with DME might lead to poor visual outcome after treatment.

Keyword

Diabetic macular edema (DME); Ganglion cell-inner plexiform layer (GCIPL); Optical coherence tomography (OCT)

MeSH Terms

Diabetic Retinopathy
Ganglion Cysts
Humans
Macular Edema*
Nerve Fibers
Retinaldehyde
Tomography, Optical Coherence
Visual Acuity*
Retinaldehyde

Figure

• 

  Figure 1. Scatter plot of end-point BCVA (log MAR) versus average pRNFL thickness, temporal pRNFL thickness, average GCIPL thickness, minimum GCIPL thickness and average CMT in DME eyes (n = 20). (A) Correlation between average pRNFL thickness and end-point BCVA. (B) Correlation between temporal pRNFL thickness and end-point BCVA. (C) Correlation between average GCIPL thickness and end-point BCVA. (D) Correlation between minimum GCIPL thickness and end-point BCVA. (E) Correlation between average CMT and end-point BCVA. BCVA = best corrected visual acuity; pRNFL = peripapillary retinal nerve fiber lay-er; GCIPL = Ganglion cell-inner plexiform layer; CMT = central macular thickness; DME = diabetic macular edema.

Reference

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