The Therapeutic Effect of Levocabastine Eye Drops on Allergic Conjunctivitis: A Multicenter Study

Kim, Hyo Myung; Kang, Shin Jeong; Kim, Ki San; Kim, Man Soo; Kim, Jae Deok; Kim, Jae Chan; Myung, Yoon Won; Park, Yeoung Gcol; Park, Woo Chan; Shin, Jong Chul; Woo, Kyung In; Lee, Jong Soo; Lee, Jong Hyuck; Leen, Chang Yeun; Lee, Ila Bum; Wee, Won Ryang; Chung, Sung Kun; Chung, Jang Ilyun; Jin, Kyung Hyun; Choi, Si Hwan; Hong, Sung Bum; Hong, Sung Pyo

Abstract

The efficacy nd tolerance of topical administration of levocabastine(0.5mg/ml)were evaluated in patients with allergic conjunctivitis. A total of 166 patients who had a typical history of atopy and a positive skin test were recruited in this study. Five clinicl symptoms(itch, tearing, chemosis, lid edema and conjunctival injection) were assessed according to a four point scale before the treatment and at 1 and 2 weeks post-therapy. Total symptom severity score before the therapy, 6.68, was remarkably decreased to 2.86 at 1 week and 2.08 at 2 weeks after the treatment. The investigators rated the treatment as globally good or excellent in 68.1% of patients checked at 1 week and 72.5% at 2 weejs after treatment. And the patients evaluated that the therapy ws good to excellent in 66.9% at 1 week and 73.1% at 2 weeks after treatment. Levocabastine eye drops has a fast onet of action with 55.4% of the patients feeling symptom relief within 15 minutes after the first administration. The adverse effect was experienced in 44 patients. Ocular irritation sign, such as foreign body sensation or soreness, was the most frequently reported complaint. These results suggest that levocabastine eye drops is an effective and safe topical alternative for treatment of allergic conjunctivitis.